5-Amino-1MQ \u2013 v\u00fdzkumn\u00e1 molekula zam\u011b\u0159en\u00e1 na metabolickou regulaci<\/p>\n
5-Amino-1MQ (5-amino-1-methylquinolinium) je syntetick\u00e1 mal\u00e1 molekula zkouman\u00e1 v oblasti bun\u011b\u010dn\u00e9ho metabolismu, energetick\u00e9 homeost\u00e1zy a regulace enzymov\u00e9 aktivity. Pat\u0159\u00ed mezi experiment\u00e1ln\u00ed inhibitory enzymu nikotinamid N-methyltransfer\u00e1za (NNMT), kter\u00fd se pod\u00edl\u00ed na metabolismu nikotinamidu a regulaci bun\u011b\u010dn\u00e9ho energetick\u00e9ho stavu.<\/p>\n
V r\u00e1mci v\u00fdzkumu je 5-Amino-1MQ p\u0159edm\u011btem z\u00e1jmu zejm\u00e9na v oblasti metabolick\u00e9 signalizace, regulace adipocyt\u016f, mitochondri\u00e1ln\u00ed funkce a molekul\u00e1rn\u00edch mechanism\u016f ovliv\u0148uj\u00edc\u00edch energetickou rovnov\u00e1hu bun\u011bk.<\/p>\n
Pro\u010d je 5-Amino-1MQ p\u0159edm\u011btem v\u00fdzkumu<\/p>\n
5-Amino-1MQ umo\u017e\u0148uje v\u00fdzkumn\u00edk\u016fm analyzovat n\u011bkolik biologick\u00fdch proces\u016f, p\u0159edev\u0161\u00edm:<\/p>\n
\u2022 regulaci aktivity enzymu NNMT
\n\u2022 metabolismus nikotinamidu a dr\u00e1hy NAD+
\n\u2022 energetick\u00fd metabolismus adipocyt\u016f
\n\u2022 signaliza\u010dn\u00ed mechanismy spojen\u00e9 s bun\u011b\u010dnou proliferac\u00ed
\n\u2022 molekul\u00e1rn\u00ed procesy souvisej\u00edc\u00ed s regulac\u00ed t\u011blesn\u00e9 kompozice v experiment\u00e1ln\u00edch modelech<\/p>\n
Mechanismus p\u016fsoben\u00ed (v\u00fdzkumn\u00fd kontext)<\/p>\n
V experiment\u00e1ln\u00edch modelech je 5-Amino-1MQ zkoum\u00e1n jako selektivn\u00ed inhibitor NNMT. Enzym NNMT hraje roli v metylaci nikotinamidu a ovliv\u0148uje dostupnost NAD+, kter\u00e1 je kl\u00ed\u010dov\u00e1 pro bun\u011b\u010dn\u00fd energetick\u00fd metabolismus a mitochondri\u00e1ln\u00ed funkci.<\/p>\n
Inhibice NNMT m\u016f\u017ee v experiment\u00e1ln\u00edch podm\u00ednk\u00e1ch v\u00e9st k:<\/p>\n
\u2022 zv\u00fd\u0161en\u00e9 dostupnosti nikotinamidu
\n\u2022 modulaci metabolismu NAD+
\n\u2022 ovlivn\u011bn\u00ed mitochondri\u00e1ln\u00ed aktivity
\n\u2022 regulaci genov\u00e9 exprese spojen\u00e9 s energetick\u00fdm metabolismem<\/p>\n
Laboratorn\u00ed studie nazna\u010duj\u00ed, \u017ee tyto mechanismy mohou b\u00fdt relevantn\u00ed pro pochopen\u00ed regulace metabolick\u00e9 rovnov\u00e1hy a bun\u011b\u010dn\u00e9 energetick\u00e9 dynamiky.<\/p>\n
Oblasti v\u00fdzkumn\u00e9ho vyu\u017eit\u00ed<\/p>\n
5-Amino-1MQ se vyu\u017e\u00edv\u00e1 zejm\u00e9na v oblastech:<\/p>\n
\u2022 v\u00fdzkum metabolick\u00e9 regulace
\n\u2022 studium enzymov\u00e9 aktivity NNMT
\n\u2022 bun\u011b\u010dn\u00e1 biologie adipocyt\u016f
\n\u2022 v\u00fdzkum metabolismu NAD+
\n\u2022 molekul\u00e1rn\u00ed mechanismy energetick\u00e9 homeost\u00e1zy<\/p>\n
V\u00fdzkumn\u00e9 podklady a v\u011bdeck\u00e9 zdroje<\/p>\n
Pou\u017eit\u00ed 5-Amino-1MQ vych\u00e1z\u00ed z \u0161ir\u0161\u00edho v\u00fdzkumu enzymu NNMT a metabolick\u00e9 regulace:<\/p>\n
1\ufe0f\u20e3 Kraus D. et al.
\nNicotine-methyltransferase regulates energy metabolism in adipose tissue
\nNature Medicine, 2014
\n\u2192 Role NNMT v regulaci energetick\u00e9ho metabolismu adipocyt\u016f.<\/p>\n
2\ufe0f\u20e3 Parsons R.B. et al.
\nThe emerging role of nicotinamide N-methyltransferase in cancer and metabolism
\nBiochemical Journal, 2011
\n\u2192 P\u0159ehled funkce NNMT v bun\u011b\u010dn\u00e9m metabolismu.<\/p>\n
3\ufe0f\u20e3 Ulanovskaya O.A. et al.
\nNNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
\nNature Chemical Biology, 2013
\n\u2192 Mechanismy ovliv\u0148ov\u00e1n\u00ed metabolick\u00fdch a epigenetick\u00fdch proces\u016f prost\u0159ednictv\u00edm NNMT.<\/p>\n
4\ufe0f\u20e3 Preklinick\u00e9 a in vitro modely
\nStudie zam\u011b\u0159en\u00e9 na metabolismus NAD+, mitochondri\u00e1ln\u00ed aktivitu a regulaci energetick\u00e9 rovnov\u00e1hy.<\/p>\n
Bezpe\u010dnostn\u00ed a regula\u010dn\u00ed informace<\/p>\n
\u26a0\ufe0f D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed:<\/p>\n
5-Amino-1MQ je ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.
\nNen\u00ed schv\u00e1len jako l\u00e9\u010divo.
\nNen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.
\nNen\u00ed ur\u010den ke konzumaci ani klinick\u00fdm aplikac\u00edm.<\/p>\n
Produkt je distribuov\u00e1n v\u00fdhradn\u011b pro v\u00fdzkumn\u00e9 instituce, laborato\u0159e a odborn\u00e9 experiment\u00e1ln\u00ed pou\u017eit\u00ed.<\/p>\n","protected":false},"excerpt":{"rendered":"
5-Amino-1MQ je syntetick\u00e1 mal\u00e1 molekula vyu\u017e\u00edvan\u00e1 pro v\u00fdzkumn\u00e9 \u00fa\u010dely v oblasti bun\u011b\u010dn\u00e9ho metabolismu a regulace enzymov\u00e9 aktivity. V experiment\u00e1ln\u00edch modelech se zkoum\u00e1 zejm\u00e9na jej\u00ed interakce s metabolick\u00fdmi drahami souvisej\u00edc\u00edmi s energetickou rovnov\u00e1hou a bun\u011b\u010dnou proliferac\u00ed.<\/p>\n
\u2705 Pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely
\n\u274c Nen\u00ed ur\u010deno pro hum\u00e1nn\u00ed pou\u017eit\u00ed<\/p>\n","protected":false},"featured_media":1019,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[155,160],"product_tag":[],"class_list":{"0":"post-1018","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-hormonalni-rovnovaha","8":"pa_dolezite-upozornenie-vsechny-produkty-dostupne-v-nasi-nabidce-jsou-urceny-vyhradne-pro-vyzkumne-laboratorni-a-vyvojove-ucely-nejsou-urceny-k-pouziti-jako-lek-zdravotnicky-prostredek-kosmeticky-pripra","9":"pa_obsah-5mg","11":"first","12":"instock","13":"purchasable","14":"product-type-simple"},"yoast_head":"\n