ACE-031 (AE1) \u2013 v\u00fdzkumn\u00fd rekombinantn\u00ed f\u00fazn\u00ed protein zam\u011b\u0159en\u00fd na regulaci svalov\u00e9ho r\u016fstu a signalizaci TGF-\u03b2<\/p>\n
ACE-031 (AE1) je rekombinantn\u00ed f\u00fazn\u00ed protein vyvinut\u00fd jako experiment\u00e1ln\u00ed n\u00e1stroj pro studium regulace svalov\u00e9 hmoty prost\u0159ednictv\u00edm modulace signaliza\u010dn\u00edch drah superrodiny TGF-\u03b2 (transforming growth factor beta). V preklinick\u00fdch a experiment\u00e1ln\u00edch modelech je p\u0159edm\u011btem v\u00fdzkumu zejm\u00e9na v oblasti inhibice myostatinu a dal\u0161\u00edch ligand\u016f typu aktivin\u016f, kter\u00e9 se pod\u00edlej\u00ed na regulaci r\u016fstu a diferenciace kostern\u00edho svalstva.<\/p>\n
Pat\u0159\u00ed mezi biologick\u00e9 molekuly zkouman\u00e9 v kontextu molekul\u00e1rn\u00ed regulace svalov\u00e9 hypertrofie, bun\u011b\u010dn\u00e9 proliferace a metabolick\u00e9 adaptace svalov\u00fdch bun\u011bk.<\/p>\n
Pro\u010d je ACE-031 p\u0159edm\u011btem v\u00fdzkumu<\/p>\n
ACE-031 umo\u017e\u0148uje v\u00fdzkumn\u00edk\u016fm analyzovat mechanismy regulace svalov\u00e9 hmoty na \u00farovni receptorov\u00e9 vazby a n\u00e1sledn\u00e9 intracelul\u00e1rn\u00ed signalizace. Je zkoum\u00e1n zejm\u00e9na v souvislosti s:<\/p>\n
\u2022 inhibic\u00ed myostatinov\u00e9 signalizace
\n\u2022 modulac\u00ed aktivinov\u00fdch receptor\u016f typu IIB (ActRIIB)
\n\u2022 regulac\u00ed diferenciace a proliferace myoblast\u016f
\n\u2022 mechanismy svalov\u00e9 hypertrofie
\n\u2022 metabolickou adaptac\u00ed kostern\u00edho svalstva
\n\u2022 interakc\u00ed mezi r\u016fstov\u00fdmi faktory a extracelul\u00e1rn\u00ed signalizac\u00ed<\/p>\n
V experiment\u00e1ln\u00edch modelech slou\u017e\u00ed jako n\u00e1stroj ke studiu biologick\u00fdch proces\u016f, kter\u00e9 ovliv\u0148uj\u00ed objem, strukturu a funk\u010dn\u00ed kapacitu svalov\u00e9 tk\u00e1n\u011b.<\/p>\n
Mechanismus p\u016fsoben\u00ed (v\u00fdzkumn\u00fd kontext)<\/p>\n
ACE-031 je navr\u017een jako f\u00fazn\u00ed protein obsahuj\u00edc\u00ed extracelul\u00e1rn\u00ed dom\u00e9nu receptoru ActRIIB, kter\u00e1 je schopna v\u00e1zat ligandy pat\u0159\u00edc\u00ed do superrodiny TGF-\u03b2, v\u010detn\u011b myostatinu. Vazbou t\u011bchto ligand\u016f m\u016f\u017ee doch\u00e1zet ke sn\u00ed\u017een\u00ed jejich biologick\u00e9 dostupnosti a n\u00e1sledn\u00e9 modulaci downstream sign\u00e1ln\u00edch drah, zejm\u00e9na SMAD-dependentn\u00edch mechanism\u016f.<\/p>\n
Laboratorn\u00ed studie nazna\u010duj\u00ed, \u017ee molekuly tohoto typu mohou ovliv\u0148ovat:<\/p>\n
\u2022 expresi gen\u016f zapojen\u00fdch do regulace svalov\u00e9ho r\u016fstu
\n\u2022 rovnov\u00e1hu mezi proteosynt\u00e9zou a proteol\u00fdzou
\n\u2022 diferenciaci svalov\u00fdch satelitn\u00edch bun\u011bk
\n\u2022 sign\u00e1ln\u00ed dr\u00e1hy reguluj\u00edc\u00ed bun\u011b\u010dn\u00fd cyklus
\n\u2022 struktur\u00e1ln\u00ed organizaci svalov\u00fdch vl\u00e1ken<\/p>\n
Tyto procesy jsou v\u00fdznamn\u00e9 pro pochopen\u00ed molekul\u00e1rn\u00ed regulace svalov\u00e9 hmoty v experiment\u00e1ln\u00edch podm\u00ednk\u00e1ch.<\/p>\n
Oblasti v\u00fdzkumn\u00e9ho vyu\u017eit\u00ed<\/p>\n
ACE-031 se vyu\u017e\u00edv\u00e1 zejm\u00e9na v oblastech:<\/p>\n
\u2022 v\u00fdzkum regulace svalov\u00e9 hypertrofie
\n\u2022 molekul\u00e1rn\u00ed biologie kostern\u00edho svalstva
\n\u2022 studium TGF-\u03b2 a myostatinov\u00e9 signalizace
\n\u2022 bun\u011b\u010dn\u00e1 diferenciace a proliferace myoblast\u016f
\n\u2022 experiment\u00e1ln\u00ed modely svalov\u00e9 atrofie a adaptace<\/p>\n
V\u00fdzkumn\u00e9 podklady a v\u011bdeck\u00e9 zdroje<\/p>\n
V\u00fdzkum inhibice myostatinu a signalizace ActRIIB vych\u00e1z\u00ed ze \u0161ir\u0161\u00edho v\u011bdeck\u00e9ho pozn\u00e1n\u00ed regulace svalov\u00e9ho r\u016fstu:<\/p>\n
1\ufe0f\u20e3 Lee S.J.
\nRegulation of muscle mass by myostatin
\nAnnual Review of Cell and Developmental Biology
\n\u2192 \u00daloha myostatinu v regulaci svalov\u00e9 hmoty.<\/p>\n
2\ufe0f\u20e3 McPherron A.C. et al.
\nRegulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
\nNature
\n\u2192 Identifikace myostatinu a jeho biologick\u00e9 funkce.<\/p>\n
3\ufe0f\u20e3 Trendy ve v\u00fdzkumu inhibitor\u016f ActRIIB
\nPreklinick\u00e9 modely zam\u011b\u0159en\u00e9 na modulaci SMAD signalizace a svalov\u00e9 hypertrofie.<\/p>\n
Bezpe\u010dnostn\u00ed a regula\u010dn\u00ed informace<\/p>\n
\u26a0\ufe0f D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed:<\/p>\n
ACE-031 je ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.
\nNen\u00ed schv\u00e1len jako l\u00e9\u010divo.
\nNen\u00ed ur\u010den k hum\u00e1nn\u00edmu ani veterin\u00e1rn\u00edmu pou\u017eit\u00ed.
\nNen\u00ed ur\u010den ke konzumaci ani klinick\u00fdm aplikac\u00edm.<\/p>\n
Produkt je distribuov\u00e1n v\u00fdhradn\u011b pro v\u00fdzkumn\u00e9 instituce, laborato\u0159e a odborn\u00e9 experiment\u00e1ln\u00ed pou\u017eit\u00ed.<\/p>\n","protected":false},"excerpt":{"rendered":"
ACE-031 (AE1) je rekombinantn\u00ed f\u00fazn\u00ed protein ur\u010den\u00fd pro v\u00fdzkumn\u00e9 \u00fa\u010dely v oblasti regulace svalov\u00e9ho r\u016fstu a signalizace superrodiny TGF-\u03b2 (transforming growth factor beta). V experiment\u00e1ln\u00edch modelech se vyu\u017e\u00edv\u00e1 ke studiu mechanism\u016f inhibice myostatinu a jeho vlivu na svalovou diferenciaci, hypertrofii a metabolickou adaptaci kostern\u00edho svalstva.<\/p>\n
Je zkoum\u00e1n zejm\u00e9na v kontextu molekul\u00e1rn\u00ed regulace svalov\u00e9 hmoty, bun\u011b\u010dn\u00e9 signalizace a interakce mezi r\u016fstov\u00fdmi faktory a svalovou tk\u00e1n\u00ed.<\/p>\n
\u2705 Pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely
\n\u274c Nen\u00ed ur\u010deno k hum\u00e1nn\u00edmu pou\u017eit\u00ed<\/p>\n","protected":false},"featured_media":1027,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[155,158,160],"product_tag":[],"class_list":{"0":"post-1026","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-fitness","8":"product_cat-hormonalni-rovnovaha","9":"pa_dolezite-upozornenie-vsechny-produkty-dostupne-v-nasi-nabidce-jsou-urceny-vyhradne-pro-vyzkumne-laboratorni-a-vyvojove-ucely-nejsou-urceny-k-pouziti-jako-lek-zdravotnicky-prostredek-kosmeticky-pripra","10":"pa_obsah-1mg","12":"first","13":"instock","14":"purchasable","15":"product-type-simple"},"yoast_head":"\n