BPC-157<\/p>\n
V\u00fdzkumn\u00fd peptid BPC-157 p\u0159edstavuje slou\u010deninu, kter\u00e1 je p\u0159edm\u011btem intenzivn\u00edho v\u011bdeck\u00e9ho zkoum\u00e1n\u00ed v souvislosti s r\u016fzn\u00fdmi typy tk\u00e1\u0148ov\u00fdch poran\u011bn\u00ed, v\u010detn\u011b l\u00e9z\u00ed org\u00e1n\u016f, \u017el\u00e1z a k\u016f\u017ee. Tato parci\u00e1ln\u00ed sekvence poch\u00e1z\u00ed z lidsk\u00e9ho \u017ealude\u010dn\u00edho ochrann\u00e9ho proteinu BPC, kter\u00fd se p\u0159irozen\u011b vyskytuje v tr\u00e1vic\u00edm traktu a byl izolov\u00e1n z lidsk\u00e9 \u017ealude\u010dn\u00ed \u0161\u0165\u00e1vy. Objevili jej v 90. letech 20. stolet\u00ed v\u011bdci zkoumaj\u00edc\u00ed jeho vliv zejm\u00e9na na funkce gastrointestin\u00e1ln\u00edho traktu a procesy hojen\u00ed.<\/p>\n
V \u0159ad\u011b studi\u00ed na bun\u011b\u010dn\u00fdch kultur\u00e1ch a zv\u00ed\u0159ec\u00edch modelech vykazoval pentadekapeptid konzistentn\u00ed biologickou aktivitu ve vztahu k proces\u016fm regenerace u r\u016fzn\u00fdch syst\u00e9mov\u00fdch \u010di traumatick\u00fdch poran\u011bn\u00ed. Experiment\u00e1ln\u00ed data nazna\u010duj\u00ed jeho souvislost s procesy t\u00fdkaj\u00edc\u00edmi se m\u011bkk\u00fdch tk\u00e1n\u00ed, sval\u016f, vaz\u016f, vnit\u0159n\u00edch org\u00e1n\u016f, k\u016f\u017ee, nervov\u00e9ho syst\u00e9mu i c\u00e9vn\u00edch struktur. V\u00fdzkum rovn\u011b\u017e zkoumal jeho vztah k gastrointestin\u00e1ln\u00edm l\u00e9z\u00edm, v\u0159ed\u016fm a z\u00e1n\u011btliv\u00fdm st\u0159evn\u00edm onemocn\u011bn\u00edm.<\/p>\n
Studie d\u00e1le uv\u00e1d\u011bj\u00ed jeho vliv na angiogenezi, produkci retikulinu a kolagenu, infiltrace makrof\u00e1g\u016f a fibroblast\u016f a modulaci lok\u00e1ln\u00edho pr\u016ftoku krve v oblasti poran\u011bn\u00ed.<\/p>\n
[1]<\/p>\n
\u00da\u010dinky zkouman\u00e9 ve v\u00fdzkumu
\n1. BPC-157 ve v\u00fdzkumu hojen\u00ed ran<\/p>\n
N\u011bkolik studi\u00ed se zam\u011b\u0159ilo na objasn\u011bn\u00ed mechanism\u016f souvisej\u00edc\u00edch s hojen\u00edm prost\u0159ednictv\u00edm BPC-157. V\u00fdzkum na potkan\u00edch modelech sledoval \u00fa\u010dinek peptidu na fibroblasty izolovan\u00e9 z Achillov\u00fdch \u0161lach. Anal\u00fdza cDNA microarray uk\u00e1zala zv\u00fd\u0161enou expresi receptoru r\u016fstov\u00e9ho hormonu ve fibroblastech \u0161lachy.<\/p>\n
Fibroblasty jsou kl\u00ed\u010dov\u00e9 bu\u0148ky pod\u00edlej\u00edc\u00ed se na ukl\u00e1d\u00e1n\u00ed protein\u016f extracelul\u00e1rn\u00ed matrix, jako jsou kolagen, fibrin \u010di elastin. BPC-157 byl ve studi\u00edch spojov\u00e1n s modulac\u00ed proliferace a migrace fibroblast\u016f v z\u00e1vislosti na d\u00e1vce a \u010dase. T\u0159et\u00ed den experimentu bylo zaznamen\u00e1no a\u017e sedmn\u00e1ctin\u00e1sobn\u00e9 zv\u00fd\u0161en\u00ed exprese receptoru GH.<\/p>\n
V modelech alkalick\u00fdch pop\u00e1lenin u potkan\u016f byl peptid zkoum\u00e1n ve vztahu k proces\u016fm tvorby granula\u010dn\u00ed tk\u00e1n\u011b, reepitelizace a remodelace k\u016f\u017ee prost\u0159ednictv\u00edm sign\u00e1ln\u00ed dr\u00e1hy ERK1\/2.<\/p>\n
[1], [2]<\/p>\n
2. Vliv BPC-157 na vaskul\u00e1rn\u00ed r\u016fst a kolateralizaci c\u00e9v<\/p>\n
Vaskul\u00e1rn\u00ed r\u016fst je z\u00e1sadn\u00ed pro regeneraci tk\u00e1n\u00ed. Studie nazna\u010duj\u00ed, \u017ee BPC-157 vykazuje angiogenn\u00ed aktivitu a m\u016f\u017ee stimulovat proliferaci endoteli\u00e1ln\u00edch bun\u011bk. \u010c\u00e1st mechanismu je spojov\u00e1na s aktivac\u00ed receptoru VEGFR2 a signalizac\u00ed oxidu dusnat\u00e9ho (NO).<\/p>\n
In vitro studie s lidsk\u00fdmi c\u00e9vn\u00edmi endoteli\u00e1ln\u00edmi bu\u0148kami prok\u00e1zaly zv\u00fd\u0161enou expresi mRNA a protein\u016f VEGFR2.<\/p>\n
V\u00fdzkum na potkanech rovn\u011b\u017e zkoumal vliv peptidu na duoden\u00e1ln\u00ed l\u00e9ze vyvolan\u00e9 \u017eiln\u00ed okluz\u00ed. BPC-157 byl spojov\u00e1n s obnoven\u00edm pr\u016ftoku krve prost\u0159ednictv\u00edm kolater\u00e1ln\u00edch c\u00e9v a modulac\u00ed syst\u00e9mu NO.<\/p>\n
Dal\u0161\u00ed experimenty nazna\u010dily jeho vliv na ischemicko-reperfuzn\u00ed po\u0161kozen\u00ed a kolitidu u zv\u00ed\u0159ec\u00edch model\u016f.<\/p>\n
[3]\u2013[9]<\/p>\n
3. BPC-157 jako cytoprotektivn\u00ed medi\u00e1tor<\/p>\n
BPC-157 byl studov\u00e1n jako gastroprotektivn\u00ed peptid ve vztahu k ochran\u011b slizni\u010dn\u00ed bari\u00e9ry tr\u00e1vic\u00edho traktu. Experiment\u00e1ln\u00ed modely nazna\u010duj\u00ed jeho spojitost s modulac\u00ed c\u00e9vn\u00edch funkc\u00ed v podm\u00ednk\u00e1ch poran\u011bn\u00ed nebo c\u00e9vn\u00ed obstrukce.<\/p>\n
[9]<\/p>\n
4. Hojen\u00ed \u0161lach a pojivov\u00fdch tk\u00e1n\u00ed<\/p>\n
Poran\u011bn\u00ed \u0161lach p\u0159edstavuj\u00ed v\u00fdznamn\u00fd klinick\u00fd probl\u00e9m. Studie in vitro a in vivo na potkan\u00edch modelech nazna\u010dily, \u017ee BPC-157 m\u016f\u017ee podporovat regeneraci \u0161lach, vaz\u016f, sval\u016f a kost\u00ed.<\/p>\n
Experimenty prok\u00e1zaly zv\u00fd\u0161enou produkci F-aktinu ve fibroblastech a aktivaci protein\u016f paxilinu a FAK, kter\u00e9 jsou kl\u00ed\u010dov\u00e9 pro bun\u011b\u010dnou migraci. Byla pops\u00e1na aktivace FAK\u2013paxilinov\u00e9 sign\u00e1ln\u00ed dr\u00e1hy.<\/p>\n
[10], [11], [12]<\/p>\n
5. Potenci\u00e1ln\u00ed antioxida\u010dn\u00ed \u00fa\u010dinky<\/p>\n
BPC-157 byl ve v\u00fdzkumu spojov\u00e1n s modulac\u00ed marker\u016f oxida\u010dn\u00edho stresu, v\u010detn\u011b oxidu dusnat\u00e9ho (NO) a malondialdehydu (MDA). Studie na zv\u00ed\u0159atech nazna\u010dily sn\u00ed\u017een\u00ed produkce reaktivn\u00edch forem kysl\u00edku v gastrointestin\u00e1ln\u00edm traktu.<\/p>\n
V experiment\u00e1ln\u00edch modelech byl BPC-157 pod\u00e1v\u00e1n prost\u0159ednictv\u00edm bakteri\u00ed Lactococcus lactis jako nosi\u010de peptidu na slizni\u010dn\u00ed povrch GI traktu.<\/p>\n
[3], [13]<\/p>\n
6. BPC-157 a vedlej\u0161\u00ed \u00fa\u010dinky n\u011bkter\u00fdch l\u00e9\u010div<\/p>\n
V\u00fdzkum na zv\u00ed\u0159atech zkoumal interakce BPC-157 s vedlej\u0161\u00edmi \u00fa\u010dinky nesteroidn\u00edch protiz\u00e1n\u011btliv\u00fdch l\u00e9\u010div (NSAID), neuroleptik, prokinetik a dal\u0161\u00edch farmakologick\u00fdch l\u00e1tek.<\/p>\n
V potkan\u00edch modelech byl sledov\u00e1n jeho vliv na prodlou\u017een\u00ed QTc intervalu a dal\u0161\u00ed kardi\u00e1ln\u00ed parametry, stejn\u011b jako jeho interakce s dopaminov\u00fdm syst\u00e9mem.<\/p>\n
[14], [15]<\/p>\n
7. V\u00fdzkum BPC-157 u v\u010del<\/p>\n
Experimenty s pod\u00e1v\u00e1n\u00edm BPC-157 ve sladk\u00e9m sirupu u v\u010del medonosn\u00fdch zkoumaly jeho vliv na infekci Nosema ceranae a syndrom zhroucen\u00ed v\u010delstev (CCD). Byla zaznamen\u00e1na zv\u00fd\u0161en\u00e1 m\u00edra p\u0159e\u017eit\u00ed koloni\u00ed a sn\u00ed\u017een\u00ed po\u0161kozen\u00ed tk\u00e1n\u00ed.<\/p>\n
[16]<\/p>\n
8. Z\u00e1v\u011br<\/p>\n
BPC-157 je p\u0159edm\u011btem rozs\u00e1hl\u00e9ho v\u00fdzkumu zejm\u00e9na na bun\u011b\u010dn\u00fdch kultur\u00e1ch a zv\u00ed\u0159ec\u00edch modelech. Je studov\u00e1n ve vztahu k proces\u016fm regenerace, angiogeneze a bun\u011b\u010dn\u00e9 signalizace. P\u0159esto\u017ee dosavadn\u00ed v\u00fdsledky experiment\u00e1ln\u00edho v\u00fdzkumu nazna\u010duj\u00ed \u0161irok\u00e9 biologick\u00e9 \u00fa\u010dinky, klinick\u00e9 studie u lid\u00ed jsou st\u00e1le omezen\u00e9.<\/p>\n
Peptid je nad\u00e1le ur\u010den v\u00fdhradn\u011b pro v\u011bdeck\u00fd a laboratorn\u00ed v\u00fdzkum.<\/p>\n","protected":false},"excerpt":{"rendered":"
BPC-157, synteticky vyroben\u00fd pentadekapeptid, je fragment proteinu Body Protective Compound (BPC), kter\u00fd byl objeven a izolov\u00e1n z lidsk\u00e9 \u017ealude\u010dn\u00ed \u0161\u0165\u00e1vy. P\u0159edstavuje sekvenci 15 aminokyselin podobnou t\u00e9, kter\u00e1 se nach\u00e1z\u00ed v lidsk\u00e9m BPC. V \u0159ad\u011b v\u00fdzkumn\u00fdch studi\u00ed na zv\u00ed\u0159atech a bun\u011b\u010dn\u00fdch kultur\u00e1ch bylo pozorov\u00e1no, \u017ee tento peptid je spojov\u00e1n se zrychlen\u00edm hojen\u00ed r\u016fzn\u00fdch typ\u016f tk\u00e1\u0148ov\u00fdch poran\u011bn\u00ed, v\u010detn\u011b \u0161lach, sval\u016f, kloub\u016f a vaz\u016f. V\u00fdzkum d\u00e1le zkoumal jeho souvislost se z\u00e1n\u011btliv\u00fdmi onemocn\u011bn\u00edmi st\u0159ev, dal\u0161\u00edmi gastrointestin\u00e1ln\u00edmi poruchami, v\u0159edy, ko\u017en\u00edmi l\u00e9zemi a tak\u00e9 s procesy prob\u00edhaj\u00edc\u00edmi v nervov\u00e9m syst\u00e9mu a c\u00e9v\u00e1ch.<\/p>\n
Experiment\u00e1ln\u00ed data nazna\u010duj\u00ed, \u017ee BPC-157 m\u016f\u017ee ovliv\u0148ovat lok\u00e1ln\u00ed pr\u016ftok krve v oblasti poran\u011bn\u00ed, kter\u00fd je za b\u011b\u017en\u00fdch podm\u00ednek omezen\u00fd, a je proto p\u0159edm\u011btem v\u00fdzkumu v souvislosti s procesy regenerace a hojen\u00ed.<\/p>\n","protected":false},"featured_media":1738,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[151,164],"product_tag":[],"class_list":["post-1726","product","type-product","status-publish","has-post-thumbnail","product_cat-pilulky","product_cat-regenerace","pa_dolezite-upozornenie-vsechny-produkty-dostupne-v-nasi-nabidce-jsou-urceny-vyhradne-pro-vyzkumne-laboratorni-a-vyvojove-ucely-nejsou-urceny-k-pouziti-jako-lek-zdravotnicky-prostredek-kosmeticky-pripra","pa_obsah-10mg","pa_obsah-500mcg","pa_obsah-5mg","first","instock","purchasable","product-type-simple"],"yoast_head":"\n