Co je Thymosin Beta-4?<\/p>\n
TB-500 je syntetick\u00fd analog p\u0159irozen\u011b se vyskytuj\u00edc\u00edho peptidu Thymosin Beta-4, kter\u00fd je v\u00fdznamn\u00fd pro regeneraci po\u0161kozen\u00fdch bun\u011bk a tk\u00e1n\u00ed. Rovn\u011b\u017e sni\u017euje tvorbu jizev a fibr\u00f3zu redukc\u00ed po\u010dtu myofibroblast\u016f v r\u00e1n\u011b a vykazuje terapeutick\u00fd potenci\u00e1l p\u0159i poran\u011bn\u00edch k\u016f\u017ee, o\u010d\u00ed, srdce a mozku. Pokroky v porozum\u011bn\u00ed jeho biologii otev\u0159ely cestu prob\u00edhaj\u00edc\u00edm a potenci\u00e1ln\u00edm klinick\u00fdm studi\u00edm zam\u011b\u0159en\u00fdm na l\u00e9\u010dbu derm\u00e1ln\u00edch ran, poran\u011bn\u00ed rohovky a regeneraci srde\u010dn\u00ed tk\u00e1n\u011b a centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu po ischemick\u00fdch inzultech \u010di traumatu.<\/p>\n
TB-500 p\u016fsob\u00ed prim\u00e1rn\u011b jako protein v\u00e1\u017e\u00edc\u00ed aktin, p\u0159i\u010dem\u017e aktin je kl\u00ed\u010dovou slo\u017ekou bun\u011b\u010dn\u00e9 struktury tvo\u0159\u00edc\u00ed mikrofilamenta. Mikrofilamenta jsou nezbytn\u00e1 pro tvar bun\u011bk, integritu membr\u00e1ny, bun\u011b\u010dn\u00fd pohyb a ur\u010dit\u00e9 f\u00e1ze bun\u011b\u010dn\u00e9 proliferace. Aktin je rovn\u011b\u017e hlavn\u00ed slo\u017ekou svalov\u00fdch protein\u016f nezbytn\u00fdch pro svalovou kontrakci. Byla provedena \u0159ada v\u00fdzkumn\u00fdch studi\u00ed, kter\u00e9 prok\u00e1zaly \u00fa\u010dinky tohoto specifick\u00e9ho peptidu.<\/p>\n
[1]<\/p>\n
\u00da\u010dinky potvrzen\u00e9 v\u00fdzkumem
\n1. TB-500 a neurologick\u00e9 \u00fa\u010dinky<\/p>\n
Thymosin \u03b24 (T\u03b24) se uk\u00e1zal jako slibn\u00e9 terapeutick\u00e9 \u010dinidlo p\u0159i poran\u011bn\u00ed m\u00edchy (SCI) d\u00edky sv\u00fdm neuroprotektivn\u00edm, protiz\u00e1n\u011btliv\u00fdm a vaskuloprotektivn\u00edm vlastnostem. Na potkan\u00edm modelu SCI vedla l\u00e9\u010dba T\u03b24 k v\u00fdznamn\u00e9mu zlep\u0161en\u00ed lokomotorick\u00e9ho zotaven\u00ed, zv\u00fd\u0161en\u00ed po\u010dtu p\u0159e\u017e\u00edvaj\u00edc\u00edch neuron\u016f a oligodendrocyt\u016f a ke sn\u00ed\u017een\u00ed z\u00e1n\u011btu ve srovn\u00e1n\u00ed s kontroln\u00ed skupinou l\u00e9\u010denou fyziologick\u00fdm roztokem. L\u00e9\u010dba T\u03b24 rovn\u011b\u017e vedla ke sn\u00ed\u017een\u00ed exprese proz\u00e1n\u011btliv\u00fdch cytokin\u016f a zv\u00fd\u0161en\u00ed hladin protiz\u00e1n\u011btliv\u00e9ho IL-10. Tato zji\u0161t\u011bn\u00ed nazna\u010duj\u00ed potenci\u00e1l T\u03b24 p\u0159i l\u00e9\u010db\u011b SCI u lid\u00ed, co\u017e podporuje jeho dosud zn\u00e1m\u00fd bezpe\u010dnostn\u00ed profil z klinick\u00fdch studi\u00ed.<\/p>\n
Krom\u011b SCI se T\u03b24 jev\u00ed jako slibn\u00e1 strategie tak\u00e9 u dal\u0161\u00edch neurologick\u00fdch poran\u011bn\u00ed a neurodegenerativn\u00edch onemocn\u011bn\u00ed. Podporuje plasticitu centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu (CNS) i perifern\u00edho nervov\u00e9ho syst\u00e9mu (PNS), neurovaskul\u00e1rn\u00ed remodelaci, angiogenezi, neurogenezi a oligodendrogenezi, co\u017e vede ke zlep\u0161en\u00ed funk\u010dn\u00edch v\u00fdsledk\u016f. Oligodendrogeneze se jev\u00ed jako kl\u00ed\u010dov\u00fd mechanismus regenera\u010dn\u00edch \u00fa\u010dink\u016f T\u03b24. Dal\u0161\u00ed v\u00fdzkum role mikroRNA (miRNA) a exozom\u00e1ln\u00edch komunika\u010dn\u00edch s\u00edt\u00ed m\u016f\u017ee objasnit molekul\u00e1rn\u00ed mechanismy neuroprotekce a regenerace zprost\u0159edkovan\u00e9 T\u03b24.<\/p>\n
T\u03b24 rovn\u011b\u017e vykazuje ochrann\u00fd \u00fa\u010dinek proti po\u0161kozen\u00ed vyvolan\u00e9mu oxida\u010dn\u00edm stresem v nervov\u00fdch kmenov\u00fdch\/progenitorov\u00fdch bu\u0148k\u00e1ch (NSPC) m\u00edchy prost\u0159ednictv\u00edm dr\u00e1hy TLR4\/MyD88. L\u00e9\u010dba T\u03b24 zvy\u0161ovala \u017eivotaschopnost bun\u011bk, sni\u017eovala apopt\u00f3zu, redukovala intracelul\u00e1rn\u00ed koncentraci v\u00e1pn\u00edku, produkci ROS i expresi proz\u00e1n\u011btliv\u00fdch cytokin\u016f. Tato zji\u0161t\u011bn\u00ed poukazuj\u00ed na jeho potenci\u00e1l p\u0159i podpo\u0159e regenerace m\u00edchy po poran\u011bn\u00ed.<\/p>\n
[2]\u2013[4]<\/p>\n
2. Thymosin Beta-4 a r\u016fst krevn\u00edch c\u00e9v<\/p>\n
T\u03b24 se pod\u00edl\u00ed na vaskul\u00e1rn\u00edm v\u00fdvoji, oprav\u011b i ochran\u011b p\u0159ed c\u00e9vn\u00edmi onemocn\u011bn\u00edmi. \u00da\u010dastn\u00ed se proces\u016f vaskulogeneze, angiogeneze, arteriogeneze, endotelov\u011b-mezenchym\u00e1ln\u00edho p\u0159echodu a remodelace extracelul\u00e1rn\u00ed matrix. Zvy\u0161uje tvorbu kapil\u00e1r a n\u00e1bor pericyt\u016f. TB-500 vykazuje stimula\u010dn\u00ed \u00fa\u010dinky na expresi VEGF, co\u017e nazna\u010duje jeho zapojen\u00ed do r\u016fstu a p\u0159estavby c\u00e9v.<\/p>\n
[5]<\/p>\n
3. Thymosin Beta-4 a r\u016fst vlas\u016f<\/p>\n
T\u03b24 se jev\u00ed jako v\u00fdznamn\u00fd regul\u00e1tor r\u016fstu vlas\u016f. Studie na potkanech a my\u0161\u00edch, v\u010detn\u011b transgenn\u00edch model\u016f s nadm\u011brnou expres\u00ed T\u03b24, prok\u00e1zaly podporu r\u016fstu vlas\u016f prost\u0159ednictv\u00edm stimulace kmenov\u00fdch bun\u011bk vlasov\u00fdch folikul\u016f, jejich migrace a diferenciace.<\/p>\n
[6]<\/p>\n
4. Thymosin Beta-4 a synergie s antibiotiky<\/p>\n
Studie zam\u011b\u0159en\u00e9 na bakteri\u00e1ln\u00ed keratitidu uk\u00e1zaly, \u017ee T\u03b24 jako dopl\u0148kov\u00e1 terapie k antibiotik\u016fm (nap\u0159. ciprofloxacinu) zlep\u0161uje hojen\u00ed ran, sni\u017euje z\u00e1n\u011bt a podporuje obrann\u00e9 mechanismy hostitele. Kombinace T\u03b24 s antibiotiky m\u016f\u017ee zv\u00fd\u0161it jejich \u00fa\u010dinnost a pomoci v boji proti multirezistentn\u00edm bakteri\u00edm.<\/p>\n
[7]<\/p>\n
5. TB-500 a kardiovaskul\u00e1rn\u00ed zdrav\u00ed<\/p>\n
Dr\u00e1ha T\u03b24\u2013Ac-SDKP vykazuje potenci\u00e1l p\u0159i l\u00e9\u010db\u011b kardiovaskul\u00e1rn\u00edch a ren\u00e1ln\u00edch onemocn\u011bn\u00ed. Ac-SDKP podporuje opravu myokardu po infarktu, angiogenezi a p\u0159e\u017e\u00edv\u00e1n\u00ed myocyt\u016f. T\u03b24 i Ac-SDKP vykazuj\u00ed antifibrotick\u00e9 a protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinky. Hydrogely obsahuj\u00edc\u00ed T\u03b24 se jev\u00ed jako slibn\u00e9 p\u0159i podpo\u0159e regenerace srde\u010dn\u00ed tk\u00e1n\u011b.<\/p>\n
[8], [9]<\/p>\n
6. TB-500 a neurodegenerativn\u00ed onemocn\u011bn\u00ed<\/p>\n
T\u03b24 indukuje autofagick\u00e9 markery LC3A\/B a Beclin1 a chr\u00e1n\u00ed p\u0159ed neurotoxicitou vyvolanou prionov\u00fdm peptidem v bun\u011b\u010dn\u00fdch modelech. Tato zji\u0161t\u011bn\u00ed nazna\u010duj\u00ed jeho potenci\u00e1l v prevenci neurodegenerativn\u00edch onemocn\u011bn\u00ed prost\u0159ednictv\u00edm podpory autofagie.<\/p>\n
[10]<\/p>\n
7. \u0160irok\u00e9 uplatn\u011bn\u00ed Thymosinu Beta-4<\/p>\n
S\u00e9rov\u00e9 hladiny T\u03b24 jsou zv\u00fd\u0161en\u00e9 u pacient\u016f s revmatoidn\u00ed artritidou a koreluj\u00ed s aktivitou onemocn\u011bn\u00ed. M\u016f\u017ee p\u0159edstavovat potenci\u00e1ln\u00ed biomarker aktivity onemocn\u011bn\u00ed a odpov\u011bdi na l\u00e9\u010dbu, av\u0161ak je nutn\u00fd dal\u0161\u00ed v\u00fdzkum.<\/p>\n
T\u03b24 rovn\u011b\u017e podporuje angiogenezi, hojen\u00ed ran a v\u00fdvoj vlasov\u00fdch folikul\u016f u experiment\u00e1ln\u00edch model\u016f. TB-500 je p\u0159edm\u011btem intenzivn\u00edho v\u00fdzkumu v oblasti kardiovaskul\u00e1rn\u00edch a neurologick\u00fdch onemocn\u011bn\u00ed. P\u0159es slibn\u00fd v\u00fdzkumn\u00fd potenci\u00e1l je TB-500 v sou\u010dasnosti ur\u010den v\u00fdhradn\u011b pro v\u011bdeck\u00e9 a vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nen\u00ed schv\u00e1len k lidsk\u00e9 spot\u0159eb\u011b.<\/p>\n","protected":false},"excerpt":{"rendered":"
Thymosin Beta-4 (T\u03b24), rovn\u011b\u017e ozna\u010dovan\u00fd jako TB-500, je syntetick\u00e1 verze p\u0159irozen\u00e9ho peptidu slo\u017een\u00e9ho ze 43 aminokyselin. Tento p\u0159irozen\u011b se vyskytuj\u00edc\u00ed peptid hraje v\u00fdznamnou roli p\u0159i oprav\u011b a regeneraci po\u0161kozen\u00fdch bun\u011bk a tk\u00e1n\u00ed prost\u0159ednictv\u00edm sn\u00ed\u017een\u00ed apopt\u00f3zy, z\u00e1n\u011btu a mikrobi\u00e1ln\u00edho r\u016fstu po poran\u011bn\u00ed. Je uvol\u0148ov\u00e1n r\u016fzn\u00fdmi typy bun\u011bk, v\u010detn\u011b krevn\u00edch desti\u010dek a makrof\u00e1g\u016f, a v\u00e1\u017ee se na aktin, \u010d\u00edm\u017e podporuje bun\u011b\u010dnou migraci a diferenciaci kmenov\u00fdch\/progenitorov\u00fdch bun\u011bk za \u00fa\u010delem tvorby nov\u00fdch krevn\u00edch c\u00e9v a regenerace tk\u00e1n\u00ed. Byl rovn\u011b\u017e zkoum\u00e1n jako prost\u0159edek pro hojen\u00ed ran a pro potenci\u00e1ln\u00ed kardiovaskul\u00e1rn\u00ed a neurologick\u00e9 \u00fa\u010dinky.<\/p>\n","protected":false},"featured_media":1762,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[155,151,164],"product_tag":[],"class_list":{"0":"post-1750","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-pilulky","8":"product_cat-regenerace","9":"pa_dolezite-upozornenie-vsechny-produkty-dostupne-v-nasi-nabidce-jsou-urceny-vyhradne-pro-vyzkumne-laboratorni-a-vyvojove-ucely-nejsou-urceny-k-pouziti-jako-lek-zdravotnicky-prostredek-kosmeticky-pripra","10":"pa_obsah-10mg","11":"pa_obsah-500mcg","12":"pa_obsah-5mg","14":"first","15":"instock","16":"purchasable","17":"product-type-simple"},"yoast_head":"\n