MGF \u2013 v\u00fdzkumn\u00fd peptid (Mechano Growth Factor)
\n(Research Use Only)<\/p>\n
MGF (Mechano Growth Factor) je izoforma inzul\u00ednu podobn\u00e9ho r\u016fstov\u00e9ho faktoru 1 (IGF-1), kter\u00e1 vznik\u00e1 jako p\u0159irozen\u00e1 odpov\u011b\u010f organismu na mechanick\u00e9 zat\u00ed\u017een\u00ed a po\u0161kozen\u00ed svalov\u00e9 tk\u00e1n\u011b. Tento peptid je p\u0159edm\u011btem v\u00fdzkumu zejm\u00e9na v oblasti svalov\u00e9 regenerace, bun\u011b\u010dn\u00e9 proliferace a adapta\u010dn\u00edch proces\u016f.<\/p>\n
Ve v\u011bdeck\u00fdch a preklinick\u00fdch studi\u00edch se MGF vyu\u017e\u00edv\u00e1 jako n\u00e1stroj pro anal\u00fdzu lok\u00e1ln\u00edch r\u016fstov\u00fdch mechanism\u016f, aktivace satelitn\u00edch bun\u011bk a opravy svalov\u00fdch vl\u00e1ken po z\u00e1t\u011b\u017ei.<\/p>\n
Mechanistick\u00fd profil<\/p>\n
Izoforma IGF-1 (Mechano Growth Factor)
\nMGF je alternativn\u011b sest\u0159i\u017een\u00e1 forma IGF-1, kter\u00e1 se exprimuje jako odpov\u011b\u010f na mechanick\u00e9 po\u0161kozen\u00ed svalov\u00e9 tk\u00e1n\u011b.<\/p>\n
Aktivace satelitn\u00edch bun\u011bk
\nV laboratorn\u00edch modelech se sleduje jeho schopnost aktivovat svalov\u00e9 satelitn\u00ed bu\u0148ky, kter\u00e9 jsou kl\u00ed\u010dov\u00e9 pro regeneraci a r\u016fst sval\u016f.<\/p>\n
Svalov\u00e1 regenerace
\nPreklinick\u00e9 studie zkoumaj\u00ed jeho vliv na opravu po\u0161kozen\u00fdch svalov\u00fdch vl\u00e1ken a obnovu tk\u00e1n\u011b.<\/p>\n
\u2699 Lok\u00e1ln\u00ed bun\u011b\u010dn\u00e1 odpov\u011b\u010f
\nMGF p\u016fsob\u00ed p\u0159ev\u00e1\u017en\u011b lok\u00e1ln\u011b v m\u00edst\u011b po\u0161kozen\u00ed, co\u017e umo\u017e\u0148uje studium specifick\u00fdch adapta\u010dn\u00edch mechanism\u016f svalov\u00e9 tk\u00e1n\u011b.<\/p>\n
Bun\u011b\u010dn\u00e1 proliferace a diferenciace
\nV\u00fdzkum se zam\u011b\u0159uje na jeho roli v regulaci r\u016fstu bun\u011bk a jejich diferenciace v r\u00e1mci svalov\u00e9 tk\u00e1n\u011b.<\/p>\n
V\u00fdhody pro v\u00fdzkum<\/p>\n
MGF je vyu\u017e\u00edv\u00e1n zejm\u00e9na v oblastech:<\/p>\n
studium svalov\u00e9 regenerace
\nanal\u00fdza aktivace satelitn\u00edch bun\u011bk
\nv\u00fdzkum IGF-1 signaliza\u010dn\u00edch drah
\nmodelov\u00e1n\u00ed adapta\u010dn\u00edch proces\u016f na mechanick\u00e9 zat\u00ed\u017een\u00ed
\nstudium bun\u011b\u010dn\u00e9 proliferace a diferenciace<\/p>\n
V\u00fdzkumn\u00e9 podklady<\/p>\n
Biologick\u00e9 vlastnosti MGF byly p\u0159edm\u011btem v\u00edce odborn\u00fdch studi\u00ed:<\/p>\n
Goldspink G., Journal of Physiology \u2013 identifikace MGF jako mechanicky indukovan\u00e9 izoformy IGF-1 a jeho role ve svalov\u00e9 adaptaci
\nYang SY et al., Journal of Muscle Research and Cell Motility \u2013 MGF stimuluje aktivaci satelitn\u00edch bun\u011bk a podporuje regeneraci sval\u016f
\nHill M., Goldspink G., Journal of Physiology \u2013 regulace svalov\u00e9ho r\u016fstu prost\u0159ednictv\u00edm IGF-1 izoforem
\nPhilippou A et al., Growth Hormone & IGF Research \u2013 role IGF-1 a jeho izoforem v bun\u011b\u010dn\u00e9 proliferaci a diferenciaci
\nExperiment\u00e1ln\u00ed modely poukazuj\u00ed na v\u00fdznam MGF p\u0159i odpov\u011bdi svalov\u00e9 tk\u00e1n\u011b na mechanick\u00e9 zat\u00ed\u017een\u00ed<\/p>\n
Pou\u017eit\u00ed ve v\u00fdzkumu<\/p>\n
MGF se v laboratorn\u00edch podm\u00ednk\u00e1ch vyu\u017e\u00edv\u00e1 zejm\u00e9na pro:<\/p>\n
v\u00fdzkum svalov\u00e9 regenerace
\nanal\u00fdzu IGF-1\/MGF signaliza\u010dn\u00edch drah
\nstudium bun\u011b\u010dn\u00e9 proliferace
\nmodelov\u00e1n\u00ed po\u0161kozen\u00ed a obnovy svalov\u00e9 tk\u00e1n\u011b
\nexperiment\u00e1ln\u00ed bun\u011b\u010dn\u00e9 a preklinick\u00e9 studie<\/p>\n
Bezpe\u010dnostn\u00ed a regula\u010dn\u00ed informace<\/p>\n
MGF je klasifikov\u00e1n jako v\u00fdzkumn\u00fd peptid.<\/p>\n
\u274c Nen\u00ed schv\u00e1len jako l\u00e9k
\n\u274c Nen\u00ed ur\u010den k diagnostice
\n\u274c Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed<\/p>\n
\u2705 Ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed a v\u011bdeck\u00fd v\u00fdzkum<\/p>\n
Zakoupen\u00edm produktu z\u00e1kazn\u00edk potvrzuje, \u017ee rozum\u00ed jeho v\u00fdzkumn\u00e9mu charakteru a zavazuje se pou\u017e\u00edvat ho v\u00fdhradn\u011b v souladu s t\u00edmto ur\u010den\u00edm.<\/p>\n","protected":false},"excerpt":{"rendered":"
MGF je v\u00fdzkumn\u00fd peptid \u2013 mechano growth faktor, izoforma IGF-1, pou\u017e\u00edvan\u00fd v laboratorn\u00edch studi\u00edch zam\u011b\u0159en\u00fdch na svalovou regeneraci a bun\u011b\u010dnou odpov\u011b\u010f na mechanick\u00e9 zat\u00ed\u017een\u00ed. V preklinick\u00e9m v\u00fdzkumu se zkoum\u00e1 jeho vliv na aktivaci satelitn\u00edch bun\u011bk, opravu svalov\u00fdch vl\u00e1ken a lok\u00e1ln\u00ed adapta\u010dn\u00ed procesy po po\u0161kozen\u00ed tk\u00e1n\u011b. Produkt je ur\u010den v\u00fdhradn\u011b pro v\u011bdeck\u00e9 \u00fa\u010dely.<\/p>\n","protected":false},"featured_media":3908,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[155,158,164],"product_tag":[],"class_list":{"0":"post-3909","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-fitness","8":"product_cat-regenerace","9":"pa_obsah-2mg","11":"first","12":"instock","13":"purchasable","14":"product-type-simple"},"yoast_head":"\n