Humanin \u2013 v\u00fdzkumn\u00fd mitochondri\u00e1ln\u00ed peptid
\n(Research Use Only)<\/p>\n
Humanin je kr\u00e1tk\u00fd mitochondri\u00e1ln\u011b odvozen\u00fd peptid (MDP), kter\u00fd se p\u0159irozen\u011b vyskytuje v organismu a je p\u0159edm\u011btem intenzivn\u00edho v\u00fdzkumu v oblasti bun\u011b\u010dn\u00e9 ochrany, metabolismu a proces\u016f st\u00e1rnut\u00ed. Byl identifikov\u00e1n jako faktor s potenci\u00e1ln\u00ed \u00falohou v ochran\u011b bun\u011bk p\u0159ed stresem a degenerativn\u00edmi procesy.<\/p>\n
Ve v\u011bdeck\u00fdch a preklinick\u00fdch studi\u00edch se Humanin vyu\u017e\u00edv\u00e1 jako n\u00e1stroj pro anal\u00fdzu mitochondri\u00e1ln\u00ed signalizace, neuroprotektivn\u00edch mechanism\u016f a regulace metabolick\u00fdch drah.<\/p>\n
Mechanistick\u00fd profil<\/p>\n
Mitochondri\u00e1ln\u011b odvozen\u00fd peptid (MDP)
\nHumanin pat\u0159\u00ed mezi peptidy k\u00f3dovan\u00e9 mitochondri\u00e1ln\u00ed DNA, kter\u00e9 se pod\u00edlej\u00ed na komunikaci mezi mitochondriemi a bun\u011b\u010dn\u00fdm j\u00e1drem.<\/p>\n
\ud83e\uddec Bun\u011b\u010dn\u00e1 ochrana (cytoprotekce)
\nV laboratorn\u00edch modelech se sleduje jeho schopnost chr\u00e1nit bu\u0148ky p\u0159ed apopt\u00f3zou a oxida\u010dn\u00edm stresem.<\/p>\n
\ud83e\udde0 Neuroprotektivn\u00ed mechanismy
\nPreklinick\u00e9 studie zkoumaj\u00ed jeho vliv na ochranu neuron\u016f a signaliza\u010dn\u00ed dr\u00e1hy spojen\u00e9 s neurodegenerac\u00ed.<\/p>\n
\u2699 Metabolick\u00e1 regulace
\nHumanin se vyu\u017e\u00edv\u00e1 pro v\u00fdzkum inzulinov\u00e9 signalizace, gluk\u00f3zov\u00e9ho metabolismu a energetick\u00e9 rovnov\u00e1hy.<\/p>\n
\ud83d\udd2c St\u00e1rnut\u00ed a longevity dr\u00e1hy
\nV\u00fdzkum poukazuje na jeho \u00falohu v procesech spojen\u00fdch se st\u00e1rnut\u00edm, v\u010detn\u011b regulace mitochondri\u00e1ln\u00ed funkce a bun\u011b\u010dn\u00e9 \u017eivotaschopnosti.<\/p>\n
V\u00fdhody pro v\u00fdzkum<\/p>\n
Humanin je vyu\u017e\u00edv\u00e1n zejm\u00e9na v oblastech:<\/p>\n
studium mitochondri\u00e1ln\u00ed signalizace
\nanal\u00fdza bun\u011b\u010dn\u00e9 ochrany a apopt\u00f3zy
\nv\u00fdzkum neurodegenerativn\u00edch proces\u016f
\nstudium metabolismu gluk\u00f3zy a inzulinov\u00e9 signalizace
\nv\u00fdzkum mechanism\u016f st\u00e1rnut\u00ed (longevity)<\/p>\n
V\u00fdzkumn\u00e9 podklady<\/p>\n
Biologick\u00e9 vlastnosti Humaninu byly p\u0159edm\u011btem n\u011bkolika odborn\u00fdch studi\u00ed:<\/p>\n
Hashimoto Y et al., Proceedings of the National Academy of Sciences (PNAS) \u2013 prvn\u00ed identifikace Humaninu jako peptidu s ochrann\u00fdm \u00fa\u010dinkem proti bun\u011b\u010dn\u00e9 smrti
\nMuzumdar RH et al., Nature Medicine \u2013 Humanin zlep\u0161uje inzulinovou citlivost a metabolick\u00e9 parametry v experiment\u00e1ln\u00edch modelech
\nYen K et al., Aging Cell \u2013 mitochondri\u00e1ln\u00ed peptidy v\u010detn\u011b Humaninu hraj\u00ed roli v regulaci st\u00e1rnut\u00ed a longevity drah
\nLee C et al., Journal of Biological Chemistry \u2013 mechanismy cytoprotekce a signalizace Humaninu
\nCobb LJ et al., Endocrinology \u2013 vliv Humaninu na metabolismus a hormon\u00e1ln\u00ed regulaci<\/p>\n
Pou\u017eit\u00ed ve v\u00fdzkumu<\/p>\n
Humanin se v laboratorn\u00edch podm\u00ednk\u00e1ch vyu\u017e\u00edv\u00e1 zejm\u00e9na pro:<\/p>\n
v\u00fdzkum mitochondri\u00e1ln\u00ed funkce a signalizace
\nanal\u00fdzu neuroprotektivn\u00edch mechanism\u016f
\nstudium metabolismu a inzulinov\u00e9 rezistence
\nmodelov\u00e1n\u00ed proces\u016f st\u00e1rnut\u00ed
\nexperiment\u00e1ln\u00ed bun\u011b\u010dn\u00e9 a preklinick\u00e9 studie<\/p>\n
Bezpe\u010dnostn\u00ed a regula\u010dn\u00ed informace<\/p>\n
Humanin je klasifikov\u00e1n jako v\u00fdzkumn\u00fd peptid.<\/p>\n
\u274c Nen\u00ed schv\u00e1len jako l\u00e9k
\n\u274c Nen\u00ed ur\u010den k diagnostice
\n\u274c Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed<\/p>\n
\u2705 Ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed a v\u011bdeck\u00fd v\u00fdzkum<\/p>\n
Zakoupen\u00edm produktu z\u00e1kazn\u00edk potvrzuje, \u017ee rozum\u00ed jeho v\u00fdzkumn\u00e9mu charakteru a zavazuje se pou\u017e\u00edvat jej v\u00fdhradn\u011b v souladu s t\u00edmto ur\u010den\u00edm.<\/p>\n","protected":false},"excerpt":{"rendered":"
Humanin je v\u00fdzkumn\u00fd peptid \u2013 mitochondri\u00e1ln\u011b odvozen\u00fd peptid, pou\u017e\u00edvan\u00fd v laboratorn\u00edch studi\u00edch zam\u011b\u0159en\u00fdch na bun\u011b\u010dnou ochranu a metabolickou regulaci. V preklinick\u00e9m v\u00fdzkumu se zkoum\u00e1 jeho vliv na apopt\u00f3zu, oxida\u010dn\u00ed stres, inzulinovou citlivost a procesy spojen\u00e9 se st\u00e1rnut\u00edm bun\u011bk. Produkt je ur\u010den v\u00fdhradn\u011b pro v\u011bdeck\u00e9 \u00fa\u010dely.<\/p>\n","protected":false},"featured_media":3926,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[155,160,164,166],"product_tag":[],"class_list":{"0":"post-3927","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-hormonalni-rovnovaha","8":"product_cat-regenerace","9":"product_cat-spanek","10":"pa_obsah-10mg","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-simple"},"yoast_head":"\n