BPC-157 + TB-500 \u2013 kombinovan\u00fd v\u00fdskumn\u00fd peptidov\u00fd komplex<\/p>\n
BPC-157 + TB-500 je kombinovan\u00fd v\u00fdskumn\u00fd peptidov\u00fd komplex obsahuj\u00faci BPC-157 (Body Protection Compound 157) a TB-500 (syntetick\u00e1 forma akt\u00edvnej sekvencie tymoz\u00ednu \u03b24). T\u00e1to kombin\u00e1cia je ur\u010den\u00e1 v\u00fdhradne na experiment\u00e1lne a preklinick\u00e9 modely zameran\u00e9 na bunkov\u00fa migr\u00e1ciu, angiogen\u00e9zu, regener\u00e1ciu tkan\u00edv a molekul\u00e1rnu signaliz\u00e1ciu s\u00favisiacu s obnovou spojivov\u00e9ho tkaniva.<\/p>\n
Oba peptidy s\u00fa predmetom vedeck\u00e9ho z\u00e1ujmu v oblasti bunkovej biol\u00f3gie, regenerat\u00edvneho v\u00fdskumu, angiogen\u00e9zy a \u0161t\u00fadia mechanizmov bunkovej odpovede na po\u0161kodenie tkaniva.<\/p>\n
Pre\u010do je BPC-157 + TB-500 predmetom v\u00fdskumu<\/p>\n
Kombin\u00e1cia t\u00fdchto peptidov umo\u017e\u0148uje v\u00fdskumn\u00edkom analyzova\u0165 komplexn\u00e9 biologick\u00e9 procesy, najm\u00e4:<\/p>\n
\u2022 bunkov\u00fa migr\u00e1ciu a prolifer\u00e1ciu
\n\u2022 procesy angiogen\u00e9zy
\n\u2022 remodel\u00e1ciu extracelul\u00e1rnej matrice
\n\u2022 regul\u00e1ciu signaliza\u010dn\u00fdch dr\u00e1h spojen\u00fdch s regener\u00e1ciou
\n\u2022 dynamiku cytoskeletu
\n\u2022 modul\u00e1ciu z\u00e1palov\u00fdch medi\u00e1torov<\/p>\n
Mechanizmus p\u00f4sobenia (v\u00fdskumn\u00fd kontext)<\/p>\n
V experiment\u00e1lnych modeloch vykazuj\u00fa jednotliv\u00e9 zlo\u017eky nasledovn\u00e9 mechanizmy:<\/p>\n
BPC-157 \u2013 syntetick\u00fd peptid odvoden\u00fd od prote\u00ednov\u00fdch sekvenci\u00ed \u017eal\u00fado\u010dnej sliznice; sk\u00fama sa jeho \u00faloha v bunkovej migr\u00e1cii, angiogen\u00e9ze, regul\u00e1cii expresie rastov\u00fdch faktorov a ochrane tkan\u00edv v preklinick\u00fdch modeloch.<\/p>\n
TB-500 (fragment tymoz\u00ednu \u03b24) \u2013 sk\u00faman\u00fd pre svoju \u00falohu v regul\u00e1cii akt\u00ednovej dynamiky, bunkovej migr\u00e1cie a procesov regener\u00e1cie tkan\u00edv; v experiment\u00e1lnych modeloch sa sp\u00e1ja s podporou bunkovej plasticity a reorganiz\u00e1cie cytoskeletu.<\/p>\n
Laborat\u00f3rne \u0161t\u00fadie nazna\u010duj\u00fa, \u017ee kombin\u00e1cia t\u00fdchto peptidov m\u00f4\u017ee ovplyv\u0148ova\u0165:<\/p>\n
\u2022 expresiu rastov\u00fdch faktorov
\n\u2022 migr\u00e1ciu fibroblastov a \u010fal\u0161\u00edch buniek spojivov\u00e9ho tkaniva
\n\u2022 procesy angiogen\u00e9zy
\n\u2022 regul\u00e1ciu z\u00e1palovej odpovede
\n\u2022 obnovu \u0161truktur\u00e1lnej integrity extracelul\u00e1rnej matrice<\/p>\n
Tieto mechanizmy s\u00fa v\u00fdznamn\u00e9 pre pochopenie biologick\u00fdch procesov regener\u00e1cie tkan\u00edv v experiment\u00e1lnom prostred\u00ed.<\/p>\n
Oblasti v\u00fdskumn\u00e9ho vyu\u017eitia<\/p>\n
BPC-157 + TB-500 sa vyu\u017e\u00edva najm\u00e4 v oblastiach:<\/p>\n
\u2022 v\u00fdskum regener\u00e1cie spojivov\u00e9ho tkaniva
\n\u2022 experiment\u00e1lne modely angiogen\u00e9zy
\n\u2022 bunkov\u00e1 migr\u00e1cia a diferenci\u00e1cia
\n\u2022 v\u00fdskum extracelul\u00e1rnej matrice
\n\u2022 molekul\u00e1rna signaliz\u00e1cia spojen\u00e1 s obnovou tkan\u00edv<\/p>\n
V\u00fdskumn\u00e9 podklady a vedeck\u00e9 zdroje<\/p>\n
Pou\u017eitie t\u00fdchto peptidov vych\u00e1dza zo \u0161ir\u0161ieho vedeck\u00e9ho v\u00fdskumu:<\/p>\n
1\ufe0f\u20e3 Sikiric P. et al.
\nStable gastric pentadecapeptide BPC 157 in therapy of gastrointestinal and other tissue injuries
\nCurrent Pharmaceutical Design, 2011
\n\u2192 Preklinick\u00e9 modely sk\u00famaj\u00face biologick\u00e9 \u00fa\u010dinky BPC-157.<\/p>\n
2\ufe0f\u20e3 Goldstein A.L. et al.
\nThymosin beta-4: Actin-sequestering protein with multiple biological activities
\nAnnals of the New York Academy of Sciences, 2007
\n\u2192 Biologick\u00e1 \u00faloha tymoz\u00ednu \u03b24 v bunkovej migr\u00e1cii a regener\u00e1cii.<\/p>\n
3\ufe0f\u20e3 Smart N. et al.
\nThymosin \u03b24 induces adult epicardial progenitor mobilization and neovascularization
\nNature, 2007
\n\u2192 Experiment\u00e1lne modely sk\u00famaj\u00face \u00falohu tymoz\u00ednu \u03b24 v angiogen\u00e9ze.<\/p>\n
4\ufe0f\u20e3 Preklinick\u00e9 a in vitro modely
\n\u0160t\u00fadie zameran\u00e9 na migr\u00e1ciu buniek, regul\u00e1ciu rastov\u00fdch faktorov a remodel\u00e1ciu extracelul\u00e1rnej matrice.<\/p>\n
Bezpe\u010dnostn\u00e1 a regula\u010dn\u00e1 inform\u00e1cia<\/p>\n
\u26a0\ufe0f D\u00f4le\u017eit\u00e9 upozornenie:<\/p>\n
BPC-157 + TB-500 je ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny a v\u00fdskumn\u00fd \u00fa\u010del.
\nNie je schv\u00e1len\u00fd ako liek.
\nNie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.
\nNie je ur\u010den\u00fd na konzum\u00e1ciu ani klinick\u00e9 aplik\u00e1cie.<\/p>\n
Produkt je distribuovan\u00fd v\u00fdhradne pre v\u00fdskumn\u00e9 in\u0161tit\u00facie, laborat\u00f3ri\u00e1 a odborn\u00e9 experiment\u00e1lne pou\u017eitie.<\/p>\n","protected":false},"excerpt":{"rendered":"
BPC-157 + TB-500 je kombinovan\u00fd v\u00fdskumn\u00fd peptidov\u00fd komplex ur\u010den\u00fd na laborat\u00f3rne \u0161t\u00fadium bunkovej migr\u00e1cie, angiogen\u00e9zy a procesov regener\u00e1cie tkan\u00edv. V experiment\u00e1lnych modeloch sa vyu\u017e\u00edva na anal\u00fdzu signaliza\u010dn\u00fdch dr\u00e1h s\u00favisiacich s obnovou spojivov\u00e9ho tkaniva, modul\u00e1ciou z\u00e1palovej odpovede a dynamikou cytoskeletu.<\/p>\n
\u2705 Len na v\u00fdskumn\u00e9 \u00fa\u010dely
\n\u274c Nie je ur\u010den\u00fd na hum\u00e1nne pou\u017eitie<\/p>\n","protected":false},"featured_media":1213,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[154,165,157],"product_tag":[],"class_list":{"0":"post-1212","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-regeneration","8":"product_cat-weight-loss","9":"pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","10":"pa_obsah-10mg","12":"first","13":"instock","14":"purchasable","15":"product-type-simple"},"yoast_head":"\n