AOD9604 \u2013 v\u00fdskumn\u00fd peptidov\u00fd fragment rastov\u00e9ho horm\u00f3nu<\/p>\n
AOD9604 je syntetick\u00fd peptidov\u00fd fragment odvoden\u00fd od C-termin\u00e1lnej \u010dasti \u013eudsk\u00e9ho rastov\u00e9ho horm\u00f3nu (hGH), konkr\u00e9tne zo sekvencie 176\u2013191. Tento fragment bol vyvinut\u00fd na experiment\u00e1lne \u00fa\u010dely s cie\u013eom izolova\u0165 metabolick\u00e9 \u00fa\u010dinky s\u00favisiace s regul\u00e1ciou lipidov\u00e9ho metabolizmu bez aktiv\u00e1cie pln\u00e9ho spektra biologick\u00fdch \u00fa\u010dinkov rastov\u00e9ho horm\u00f3nu.<\/p>\n
V r\u00e1mci v\u00fdskumu je AOD9604 predmetom z\u00e1ujmu najm\u00e4 v oblasti metabolickej regul\u00e1cie, lipol\u00fdzy, signaliz\u00e1cie adipocytov a \u0161t\u00fadia mechanizmov energetickej homeost\u00e1zy.<\/p>\n
Pre\u010do je AOD9604 predmetom v\u00fdskumu<\/p>\n
AOD9604 umo\u017e\u0148uje v\u00fdskumn\u00edkom analyzova\u0165 viacer\u00e9 biologick\u00e9 procesy, predov\u0161etk\u00fdm:<\/p>\n
\u2022 regul\u00e1ciu metabolizmu tukov
\n\u2022 lipolytick\u00e9 a lipog\u00e9nne procesy v adipocytoch
\n\u2022 signaliza\u010dn\u00e9 dr\u00e1hy s\u00favisiace s hormon\u00e1lnou regul\u00e1ciou energetickej rovnov\u00e1hy
\n\u2022 bunkov\u00fa odpove\u010f na fragmenty rastov\u00e9ho horm\u00f3nu
\n\u2022 molekul\u00e1rne mechanizmy regul\u00e1cie telesnej kompoz\u00edcie v experiment\u00e1lnych modeloch<\/p>\n
Mechanizmus p\u00f4sobenia (v\u00fdskumn\u00fd kontext)<\/p>\n
V experiment\u00e1lnych modeloch je AOD9604 sk\u00faman\u00fd ako selekt\u00edvny fragment rastov\u00e9ho horm\u00f3nu, ktor\u00fd si zachov\u00e1va schopnos\u0165 ovplyv\u0148ova\u0165 lipidov\u00fd metabolizmus bez v\u00fdraznej stimul\u00e1cie IGF-1 osi. Predpoklad\u00e1 sa, \u017ee jeho \u00fa\u010dinok je sprostredkovan\u00fd interakciou s receptorov\u00fdmi a postreceptorov\u00fdmi signaliza\u010dn\u00fdmi mechanizmami zapojen\u00fdmi do regul\u00e1cie lipol\u00fdzy.<\/p>\n
Laborat\u00f3rne \u0161t\u00fadie nazna\u010duj\u00fa, \u017ee AOD9604 m\u00f4\u017ee ovplyv\u0148ova\u0165:<\/p>\n
\u2022 aktivitu enz\u00fdmov zapojen\u00fdch do lipol\u00fdzy
\n\u2022 metabolick\u00fa aktivitu adipocytov
\n\u2022 regul\u00e1ciu expresie g\u00e9nov s\u00favisiacich s metabolizmom lipidov
\n\u2022 signaliza\u010dn\u00e9 dr\u00e1hy ovplyv\u0148uj\u00face energetick\u00fa rovnov\u00e1hu<\/p>\n
Tieto mechanizmy s\u00fa v\u00fdznamn\u00e9 pre pochopenie hormon\u00e1lnej regul\u00e1cie metabolizmu tukov v experiment\u00e1lnom prostred\u00ed.<\/p>\n
Oblasti v\u00fdskumn\u00e9ho vyu\u017eitia<\/p>\n
AOD9604 sa vyu\u017e\u00edva najm\u00e4 v oblastiach:<\/p>\n
\u2022 v\u00fdskum lipidov\u00e9ho metabolizmu
\n\u2022 experiment\u00e1lne modely regul\u00e1cie telesnej kompoz\u00edcie
\n\u2022 \u0161t\u00fadium hormon\u00e1lnej signaliz\u00e1cie
\n\u2022 bunkov\u00e1 biol\u00f3gia adipocytov
\n\u2022 molekul\u00e1rna regul\u00e1cia energetickej homeost\u00e1zy<\/p>\n
V\u00fdskumn\u00e9 podklady a vedeck\u00e9 zdroje<\/p>\n
Pou\u017eitie AOD9604 vych\u00e1dza zo \u0161ir\u0161ieho v\u00fdskumu fragmentov rastov\u00e9ho horm\u00f3nu:<\/p>\n
1\ufe0f\u20e3 Ng F.M. et al.
\nHuman growth hormone: the molecular mechanism of the lipolytic effect
\nJournal of Molecular Endocrinology, 2000
\n\u2192 Mechanizmy lipolytick\u00e9ho p\u00f4sobenia fragmentov rastov\u00e9ho horm\u00f3nu.<\/p>\n
2\ufe0f\u20e3 Heffernan M.A. et al.
\nThe metabolic effects of a growth hormone fragment (AOD9604)
\nEndocrine, 2001
\n\u2192 Experiment\u00e1lne modely sk\u00famaj\u00face metabolick\u00e9 \u00fa\u010dinky fragmentu 176\u2013191.<\/p>\n
3\ufe0f\u20e3 Bak J.F. et al.
\nGrowth hormone action on lipid metabolism
\nHormone Research, 1999
\n\u2192 \u00daloha rastov\u00e9ho horm\u00f3nu a jeho fragmentov v regul\u00e1cii lipidov\u00e9ho metabolizmu.<\/p>\n
4\ufe0f\u20e3 Preklinick\u00e9 modely (in vitro \/ in vivo)
\n\u0160t\u00fadie zameran\u00e9 na lipol\u00fdzu, expresiu metabolick\u00fdch g\u00e9nov a regul\u00e1ciu energetickej rovnov\u00e1hy.<\/p>\n
Bezpe\u010dnostn\u00e1 a regula\u010dn\u00e1 inform\u00e1cia<\/p>\n
\u26a0\ufe0f D\u00f4le\u017eit\u00e9 upozornenie:<\/p>\n
AOD9604 je ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny a v\u00fdskumn\u00fd \u00fa\u010del.
\nNie je schv\u00e1len\u00fd ako liek.
\nNie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.
\nNie je ur\u010den\u00fd na konzum\u00e1ciu ani klinick\u00e9 aplik\u00e1cie.<\/p>\n
Produkt je distribuovan\u00fd v\u00fdhradne pre v\u00fdskumn\u00e9 in\u0161tit\u00facie, laborat\u00f3ri\u00e1 a odborn\u00e9 experiment\u00e1lne pou\u017eitie.<\/p>\n","protected":false},"excerpt":{"rendered":"
AOD9604 je syntetick\u00fd peptidov\u00fd fragment odvoden\u00fd od rastov\u00e9ho horm\u00f3nu, ur\u010den\u00fd na v\u00fdskumn\u00e9 \u00fa\u010dely v oblasti metabolizmu tukov, lipolytick\u00fdch procesov a regul\u00e1cie energetickej rovnov\u00e1hy. V experiment\u00e1lnych modeloch sa vyu\u017e\u00edva na \u0161t\u00fadium signaliza\u010dn\u00fdch dr\u00e1h s\u00favisiacich s metabolizmom lipidov a bunkovou odpove\u010fou na hormon\u00e1lne podnety.<\/p>\n
\u2705 Len na v\u00fdskumn\u00e9 \u00fa\u010dely
\n\u274c Nie je ur\u010den\u00fd na hum\u00e1nne pou\u017eitie<\/p>\n","protected":false},"featured_media":1217,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[154,161,165],"product_tag":[],"class_list":{"0":"post-1216","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-hormonal-balance","8":"product_cat-regeneration","9":"pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","10":"pa_obsah-10-mg","11":"pa_obsah-5mg","13":"first","14":"instock","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"yoast_head":"\n