SS-31 (Elamipretide) \u2013 mitochondri\u00e1lne cielen\u00fd v\u00fdskumn\u00fd peptid<\/p>\n
SS-31, zn\u00e1my aj ako elamipretide, je syntetick\u00fd mitochondri\u00e1lne cielen\u00fd tetrapeptid vyvinut\u00fd na experiment\u00e1lne \u00fa\u010dely v oblasti bunkovej bioenergetiky, regul\u00e1cie oxida\u010dn\u00e9ho stresu a \u0161t\u00fadia mitochondri\u00e1lnej integrity. Patr\u00ed medzi tzv. mitochondria-targeting peptides (MTPs), ktor\u00e9 s\u00fa navrhnut\u00e9 tak, aby selekt\u00edvne interagovali s mitochondri\u00e1lnymi membr\u00e1nami.<\/p>\n
Vo v\u00fdskumnom kontexte je SS-31 predmetom z\u00e1ujmu najm\u00e4 v oblasti mitochondri\u00e1lnej fyziol\u00f3gie, regul\u00e1cie reakt\u00edvnych foriem kysl\u00edka (ROS), stabiliz\u00e1cie kardiolip\u00ednu a mechanizmov ovplyv\u0148uj\u00facich bunkov\u00fd energetick\u00fd metabolizmus.<\/p>\n
Pre\u010do je SS-31 predmetom v\u00fdskumu<\/p>\n
SS-31 umo\u017e\u0148uje v\u00fdskumn\u00edkom analyzova\u0165 viacer\u00e9 komplexn\u00e9 biologick\u00e9 procesy, predov\u0161etk\u00fdm:<\/p>\n
\u2022 mitochondri\u00e1lnu funkciu a bioenergetick\u00fa kapacitu buniek
\n\u2022 regul\u00e1ciu produkcie reakt\u00edvnych foriem kysl\u00edka (ROS)
\n\u2022 stabilitu mitochondri\u00e1lnej vn\u00fatornej membr\u00e1ny
\n\u2022 interakciu s kardiolip\u00ednom
\n\u2022 bunkov\u00fa odpove\u010f na oxida\u010dn\u00fd a metabolick\u00fd stres<\/p>\n
Mechanizmus p\u00f4sobenia (v\u00fdskumn\u00fd kontext)<\/p>\n
V experiment\u00e1lnych modeloch je SS-31 sk\u00faman\u00fd ako peptid schopn\u00fd selekt\u00edvne lokalizova\u0165 do mitochondri\u00ed a viaza\u0165 sa na kardiolip\u00edn \u2013 fosfolipid nach\u00e1dzaj\u00faci sa vo vn\u00fatornej mitochondri\u00e1lnej membr\u00e1ne. Stabiliz\u00e1cia kardiolip\u00ednu m\u00f4\u017ee prispieva\u0165 k zachovaniu \u0161truktur\u00e1lnej integrity mitochondri\u00e1lnych membr\u00e1n a optimaliz\u00e1cii funkcie elektr\u00f3nov\u00e9ho transportn\u00e9ho re\u0165azca.<\/p>\n
Laborat\u00f3rne \u0161t\u00fadie nazna\u010duj\u00fa, \u017ee SS-31 m\u00f4\u017ee ovplyv\u0148ova\u0165:<\/p>\n
\u2022 efektivitu mitochondri\u00e1lneho d\u00fdchania
\n\u2022 produkciu ATP
\n\u2022 regul\u00e1ciu oxida\u010dn\u00e9ho stresu
\n\u2022 apoptotick\u00e9 signaliza\u010dn\u00e9 dr\u00e1hy
\n\u2022 bunkov\u00fa energetick\u00fa homeost\u00e1zu<\/p>\n
Tieto mechanizmy s\u00fa v\u00fdznamn\u00e9 pre pochopenie \u00falohy mitochondri\u00ed v bunkovej fyziol\u00f3gii a metabolickej regul\u00e1cii v experiment\u00e1lnom prostred\u00ed.<\/p>\n
Oblasti v\u00fdskumn\u00e9ho vyu\u017eitia<\/p>\n
SS-31 sa vyu\u017e\u00edva najm\u00e4 v oblastiach:<\/p>\n
\u2022 v\u00fdskum mitochondri\u00e1lnej bioenergetiky
\n\u2022 \u0161t\u00fadium oxida\u010dn\u00e9ho stresu
\n\u2022 experiment\u00e1lne modely metabolickej dysfunkcie
\n\u2022 molekul\u00e1rna regul\u00e1cia apopt\u00f3zy
\n\u2022 bunkov\u00e1 fyziol\u00f3gia a energetick\u00e1 homeost\u00e1za<\/p>\n
V\u00fdskumn\u00e9 podklady a vedeck\u00e9 zdroje<\/p>\n
Pou\u017eitie SS-31 vych\u00e1dza zo \u0161ir\u0161ieho v\u00fdskumu mitochondri\u00e1lne cielen\u00fdch peptidov:<\/p>\n
1\ufe0f\u20e3 Szeto H.H., Schiller P.W.
\nNovel therapies targeting inner mitochondrial membrane \u2013 from discovery to clinical development
\nPharmacological Research, 2011
\n\u2192 V\u00fdvoj a mechanizmus mitochondri\u00e1lne cielen\u00fdch peptidov vr\u00e1tane SS-31.<\/p>\n
2\ufe0f\u20e3 Birk A.V. et al.
\nTargeting mitochondrial cardiolipin and the cytochrome c\/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis
\nBritish Journal of Pharmacology, 2013
\n\u2192 Interakcia SS-31 s kardiolip\u00ednom a vplyv na mitochondri\u00e1lnu funkciu.<\/p>\n
3\ufe0f\u20e3 Dai D.F. et al.
\nMitochondrial oxidative stress in aging and healthspan
\nFree Radical Biology & Medicine, 2014
\n\u2192 \u00daloha mitochondri\u00e1lneho oxida\u010dn\u00e9ho stresu v bunkovej fyziol\u00f3gii.<\/p>\n
4\ufe0f\u20e3 Preklinick\u00e9 a in vitro modely
\n\u0160t\u00fadie zameran\u00e9 na mitochondri\u00e1lnu respir\u00e1ciu, produkciu ATP a regul\u00e1ciu ROS.<\/p>\n
Bezpe\u010dnostn\u00e1 a regula\u010dn\u00e1 inform\u00e1cia<\/p>\n
\u26a0\ufe0f D\u00f4le\u017eit\u00e9 upozornenie:<\/p>\n
SS-31 je ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny a v\u00fdskumn\u00fd \u00fa\u010del.
\nNie je schv\u00e1len\u00fd ako liek.
\nNie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.
\nNie je ur\u010den\u00fd na konzum\u00e1ciu ani klinick\u00e9 aplik\u00e1cie.<\/p>\n
Produkt je distribuovan\u00fd v\u00fdhradne pre v\u00fdskumn\u00e9 in\u0161tit\u00facie, laborat\u00f3ri\u00e1 a odborn\u00e9 experiment\u00e1lne pou\u017eitie.<\/p>\n","protected":false},"excerpt":{"rendered":"
SS-31 (elamipretide) je syntetick\u00fd mitochondri\u00e1lne cielen\u00fd peptid ur\u010den\u00fd na v\u00fdskumn\u00e9 \u00fa\u010dely v oblasti bunkovej bioenergetiky a regul\u00e1cie oxida\u010dn\u00e9ho stresu. V experiment\u00e1lnych modeloch sa vyu\u017e\u00edva na \u0161t\u00fadium mitochondri\u00e1lnej funkcie, stability membr\u00e1nov\u00fdch \u0161trukt\u00far a signaliza\u010dn\u00fdch mechanizmov s\u00favisiacich s energetick\u00fdm metabolizmom buniek.<\/p>\n
\u2705 Len na v\u00fdskumn\u00e9 \u00fa\u010dely
\n\u274c Nie je ur\u010den\u00fd na hum\u00e1nne pou\u017eitie<\/p>\n","protected":false},"featured_media":1221,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[154,161],"product_tag":[],"class_list":{"0":"post-1220","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-hormonal-balance","8":"pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","9":"pa_obsah-10mg","10":"pa_obsah-50mg","12":"first","13":"instock","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"yoast_head":"\n