ACE-031 (AE1) \u2013 a research recombinant fusion protein focused on muscle growth regulation and TGF-\u03b2 signaling<\/p>\n
ACE-031 (AE1) is a recombinant fusion protein developed as an experimental tool for studying muscle mass regulation through modulation of signaling pathways within the TGF-\u03b2 (transforming growth factor beta) superfamily. In preclinical and experimental models, it is primarily investigated in the context of myostatin inhibition and related activin-type ligands involved in the regulation of skeletal muscle growth and differentiation.<\/p>\n
It belongs to a class of biologically active molecules studied in relation to molecular control of muscle hypertrophy, cellular proliferation, and metabolic adaptation of muscle tissue.<\/p>\n
Why ACE-031 Is a Subject of Research<\/p>\n
ACE-031 enables researchers to analyze muscle mass regulatory mechanisms at the level of receptor binding and downstream intracellular signaling. It is primarily studied in relation to:<\/p>\n
\u2022 inhibition of myostatin signaling
\n\u2022 modulation of activin type IIB receptors (ActRIIB)
\n\u2022 regulation of myoblast differentiation and proliferation
\n\u2022 mechanisms of skeletal muscle hypertrophy
\n\u2022 metabolic adaptation of skeletal muscle tissue
\n\u2022 interactions between growth factors and extracellular signaling pathways<\/p>\n
In experimental models, it serves as a research tool for investigating biological processes influencing muscle volume, structural organization, and functional capacity.<\/p>\n
Mechanism of Action (Research Context)<\/p>\n
ACE-031 is engineered as a fusion protein containing the extracellular domain of the ActRIIB receptor, capable of binding ligands belonging to the TGF-\u03b2 superfamily, including myostatin. By binding these ligands, their biological availability may be reduced, leading to modulation of downstream signaling cascades, particularly SMAD-dependent pathways.<\/p>\n
Laboratory research suggests that molecules of this type may influence:<\/p>\n
\u2022 gene expression involved in muscle growth regulation
\n\u2022 the balance between protein synthesis and proteolysis
\n\u2022 differentiation of muscle satellite cells
\n\u2022 signaling pathways regulating the cell cycle
\n\u2022 structural organization of muscle fibers<\/p>\n
These mechanisms are significant for understanding molecular regulation of muscle mass under experimental conditions.<\/p>\n
Areas of Research Application<\/p>\n
ACE-031 is primarily utilized in:<\/p>\n
\u2022 research on skeletal muscle hypertrophy regulation
\n\u2022 molecular biology of skeletal muscle tissue
\n\u2022 studies of TGF-\u03b2 and myostatin signaling pathways
\n\u2022 cellular differentiation and myoblast proliferation models
\n\u2022 experimental models of muscle atrophy and adaptation<\/p>\n
Research Background and Scientific References<\/p>\n
Research on myostatin inhibition and ActRIIB signaling is supported by extensive scientific literature on muscle growth regulation:<\/p>\n
1\ufe0f\u20e3 Lee S.J.
\nRegulation of muscle mass by myostatin
\nAnnual Review of Cell and Developmental Biology
\n\u2192 Role of myostatin in muscle mass regulation.<\/p>\n
2\ufe0f\u20e3 McPherron A.C. et al.
\nRegulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
\nNature
\n\u2192 Identification and biological function of myostatin.<\/p>\n
3\ufe0f\u20e3 Emerging research on ActRIIB inhibitors
\nPreclinical models investigating SMAD signaling modulation and skeletal muscle hypertrophy.<\/p>\n
Safety and Regulatory Information<\/p>\n
\u26a0\ufe0f Important Notice:<\/p>\n
ACE-031 is intended strictly for laboratory and research purposes.
\nIt is not approved as a medicinal product.
\nIt is not intended for human or veterinary use.
\nIt is not intended for consumption or clinical applications.<\/p>\n
The product is distributed exclusively to research institutions, laboratories, and professional experimental use.<\/p>\n","protected":false},"excerpt":{"rendered":"
ACE-031 (AE1) is a recombinant fusion protein intended for research purposes in the field of muscle growth regulation and TGF-\u03b2 (transforming growth factor beta) superfamily signaling. In experimental models, it is utilized to study mechanisms of myostatin inhibition and its influence on muscle differentiation, hypertrophy, and metabolic adaptation of skeletal muscle tissue.<\/p>\n
It is primarily investigated in the context of molecular regulation of muscle mass, cellular signaling pathways, and interactions between growth factors and muscle tissue.<\/p>\n
\u2705 For research purposes only
\n\u274c Not intended for human use<\/p>\n","protected":false},"featured_media":1227,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[154,159,161],"product_tag":[],"class_list":{"0":"post-1226","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-fitness","8":"product_cat-hormonal-balance","9":"pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","10":"pa_obsah-1mg","12":"first","13":"instock","14":"purchasable","15":"product-type-simple"},"yoast_head":"\n