Adipotide \u2013 v\u00fdskumn\u00fd peptid
\nAdipotide (zn\u00e1my aj ako Prohibitin-targeting peptide) je syntetick\u00fd v\u00fdskumn\u00fd peptid vyvinut\u00fd na experiment\u00e1lne \u0161t\u00fadium selekt\u00edvnej elimin\u00e1cie tukov\u00fdch buniek a mechanizmov regul\u00e1cie telesnej kompoz\u00edcie. Pou\u017e\u00edva sa v preklinick\u00fdch a laborat\u00f3rnych modeloch zameran\u00fdch na metabolizmus tukov\u00e9ho tkaniva, energetick\u00fa bilanciu a biologick\u00e9 procesy spojen\u00e9 s obezitou.<\/p>\n
Adipotide je predmetom intenz\u00edvneho v\u00fdskumu v oblasti metabolickej biol\u00f3gie, adipocytovej signaliz\u00e1cie a regul\u00e1cie tukov\u00fdch z\u00e1sob.<\/p>\n
Pre\u010do je Adipotide predmetom v\u00fdskumu
\nAdipotide umo\u017e\u0148uje vedcom analyzova\u0165 viacero k\u013e\u00fa\u010dov\u00fdch metabolick\u00fdch procesov:<\/p>\n
Selekt\u00edvna redukcia tukov\u00e9ho tkaniva<\/p>\n
Regul\u00e1cia adipocytovej apopt\u00f3zy<\/p>\n
\u0160t\u00fadium energetickej rovnov\u00e1hy<\/p>\n
Anal\u00fdza metabolick\u00fdch dr\u00e1h<\/p>\n
Modelovanie mechanizmov obezity<\/p>\n
Mechanizmus p\u00f4sobenia (v\u00fdskumn\u00fd kontext)
\nV experiment\u00e1lnych podmienkach sa Adipotide via\u017ee na prohibitinov\u00e9 receptory, ktor\u00e9 s\u00fa selekt\u00edvne exprimovan\u00e9 na povrchu krvn\u00fdch ciev z\u00e1sobuj\u00facich tukov\u00e9 tkanivo. T\u00e1to v\u00e4zba sp\u00fa\u0161\u0165a apoptotick\u00e9 procesy v adipocytoch prostredn\u00edctvom naru\u0161enia mitochondri\u00e1lnej funkcie.<\/p>\n
V\u00fdskumn\u00edci pou\u017e\u00edvaj\u00fa Adipotide v bunkov\u00fdch modeloch a preklinick\u00fdch \u0161t\u00fadi\u00e1ch na sledovanie zmien v tukovom tkanive, energetickom metabolizme a telesnej kompoz\u00edcii.<\/p>\n
Oblasti v\u00fdskumn\u00e9ho vyu\u017eitia
\nAdipotide sa vyu\u017e\u00edva najm\u00e4 v oblastiach:<\/p>\n
Metabolick\u00fd v\u00fdskum<\/p>\n
V\u00fdskum obezity<\/p>\n
Biol\u00f3gia tukov\u00e9ho tkaniva<\/p>\n
Energetick\u00e1 rovnov\u00e1ha buniek<\/p>\n
Molekul\u00e1rna signaliz\u00e1cia<\/p>\n
V\u00fdskumn\u00e9 podklady a vedeck\u00e9 zdroje
\nPou\u017eitie Adipotide je podlo\u017een\u00e9 v\u00fdznamn\u00fdmi publikovan\u00fdmi \u0161t\u00fadiami:<\/p>\n
1\ufe0f\u20e3 Kolonin M.G. et al.
\nReversal of obesity by targeted ablation of adipose tissue,
\nScience, 2004
\n\u2192 Prelomov\u00e1 preklinick\u00e1 \u0161t\u00fadia demon\u0161truj\u00faca selekt\u00edvne cielenie tukov\u00e9ho tkaniva pomocou peptidov a indukciu apopt\u00f3zy adipocytov.<\/p>\n
2\ufe0f\u20e3 Barnhart K.F. et al.
\nSelective targeting of adipose vasculature and fat reduction using prohibitin-binding peptides,
\nProceedings of the National Academy of Sciences (PNAS), 2011
\n\u2192 V\u00fdskum zameran\u00fd na mechanizmus v\u00e4zby Adipotide na adip\u00f3zne cievne receptory a metabolick\u00e9 d\u00f4sledky tejto interakcie.<\/p>\n
3\ufe0f\u20e3 Preklinick\u00e9 modely (in vivo \/ in vitro)
\nExperiment\u00e1lne \u0161t\u00fadie sleduj\u00face zmeny v metabolizme tukov\u00e9ho tkaniva, apopt\u00f3ze adipocytov a regul\u00e1cii energetickej bilancie.<\/p>\n
Bezpe\u010dnostn\u00e1 a regula\u010dn\u00e1 inform\u00e1cia
\n\u26a0\ufe0f D\u00f4le\u017eit\u00e9 upozornenie:<\/p>\n
Adipotide je ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny a v\u00fdskumn\u00fd \u00fa\u010del<\/p>\n
Nie je schv\u00e1len\u00fd ako liek<\/p>\n
Nie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie<\/p>\n
Nie je ur\u010den\u00fd na konzum\u00e1ciu alebo klinick\u00e9 aplik\u00e1cie<\/p>\n","protected":false},"excerpt":{"rendered":"
Adipotide je v\u00fdskumn\u00fd peptid pou\u017e\u00edvan\u00fd v laborat\u00f3rnych modeloch na \u0161t\u00fadium selekt\u00edvnej redukcie tukov\u00e9ho tkaniva, metabolick\u00fdch dr\u00e1h a regul\u00e1cie energetickej rovnov\u00e1hy.<\/p>\n
\u2705 Len na v\u00fdskumn\u00e9 \u00fa\u010dely
\n\u274c Nie je ur\u010den\u00fd na hum\u00e1nne pou\u017eitie<\/p>\n
Obsah:<\/strong> 2mg<\/p>\n","protected":false},"featured_media":2052,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[159,161,157],"product_tag":[],"class_list":{"0":"post-1240","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-fitness","7":"product_cat-hormonal-balance","8":"product_cat-weight-loss","9":"pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","10":"pa_obsah-2mg","12":"first","13":"instock","14":"purchasable","15":"product-type-simple"},"yoast_head":"\n