AICAR \u2013 v\u00fdskumn\u00fd peptid
\nAICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) je syntetick\u00fd v\u00fdskumn\u00fd peptidov\u00fd anal\u00f3g nukleotidu, ktor\u00fd sa pou\u017e\u00edva v experiment\u00e1lnych a preklinick\u00fdch \u0161t\u00fadi\u00e1ch na aktiv\u00e1ciu AMP-activated protein kinase (AMPK) \u2013 centr\u00e1lneho regul\u00e1tora bunkovej energetickej rovnov\u00e1hy. Tento peptid predstavuje k\u013e\u00fa\u010dov\u00fd n\u00e1stroj pre v\u00fdskum metabolizmu, bunkovej adapt\u00e1cie na energetick\u00fd stres a anti-aging mechanizmov.<\/p>\n
AICAR sa vyu\u017e\u00edva v laborat\u00f3rnych modeloch na simul\u00e1ciu energetick\u00e9ho deficitu buniek a \u0161t\u00fadium metabolickej plasticity.<\/p>\n
Pre\u010do je AICAR predmetom v\u00fdskumu
\nAICAR umo\u017e\u0148uje vedcom analyzova\u0165 viacero z\u00e1sadn\u00fdch biologick\u00fdch procesov:<\/p>\n
Aktiv\u00e1cia AMPK sign\u00e1lnej dr\u00e1hy<\/p>\n
Regul\u00e1cia bunkov\u00e9ho energetick\u00e9ho metabolizmu<\/p>\n
\u0160t\u00fadium mitochondri\u00e1lnej aktivity<\/p>\n
V\u00fdskum metabolickej adapt\u00e1cie buniek<\/p>\n
Modelovanie anti-aging mechanizmov<\/p>\n
Mechanizmus p\u00f4sobenia (v\u00fdskumn\u00fd kontext)
\nV experiment\u00e1lnych podmienkach AICAR p\u00f4sob\u00ed ako intracelul\u00e1rny aktiv\u00e1tor AMPK, \u010d\u00edm simuluje stav n\u00edzkej energetickej dostupnosti. Aktiv\u00e1cia AMPK vedie k regul\u00e1cii metabolick\u00fdch dr\u00e1h zodpovedn\u00fdch za produkciu energie, bunkov\u00fa obnovu, autof\u00e1giu a adapt\u00e1ciu buniek na stresov\u00e9 podmienky.<\/p>\n
V\u00fdskumn\u00edci pou\u017e\u00edvaj\u00fa AICAR v bunkov\u00fdch kult\u00farach a preklinick\u00fdch modeloch na sledovanie metabolickej rovnov\u00e1hy, regener\u00e1cie buniek a procesov spojen\u00fdch s bunkov\u00fdm starnut\u00edm.<\/p>\n
Oblasti v\u00fdskumn\u00e9ho vyu\u017eitia
\nAICAR sa vyu\u017e\u00edva najm\u00e4 v oblastiach:<\/p>\n
Metabolick\u00fd v\u00fdskum<\/p>\n
V\u00fdskum bunkovej energetiky<\/p>\n
Anti-aging v\u00fdskum<\/p>\n
Mitochondri\u00e1lna biol\u00f3gia<\/p>\n
Molekul\u00e1rna signaliz\u00e1cia<\/p>\n
V\u00fdskumn\u00e9 podklady a vedeck\u00e9 zdroje
\nPou\u017eitie AICAR je podlo\u017een\u00e9 rozsiahlymi publikovan\u00fdmi \u0161t\u00fadiami:<\/p>\n
1\ufe0f\u20e3 Narkar V.A. et al.
\nAMPK activation enhances endurance and metabolic gene expression in skeletal muscle,
\nCell Metabolism, 2008
\n\u2192 Preklinick\u00e1 \u0161t\u00fadia demon\u0161truj\u00faca \u00falohu AICAR pri aktiv\u00e1cii AMPK a regul\u00e1cii metabolick\u00fdch dr\u00e1h spojen\u00fdch s energetickou adapt\u00e1ciou buniek.<\/p>\n
2\ufe0f\u20e3 Hardie D.G. et al.
\nAMPK: a key regulator of energy balance in cells,
\nNature Reviews Molecular Cell Biology, 2012
\n\u2192 Preh\u013eadov\u00e1 publik\u00e1cia popisuj\u00faca mechanizmy AMPK aktiv\u00e1cie a jej \u00falohu v metabolizme, bunkovej regener\u00e1cii a starnut\u00ed.<\/p>\n
3\ufe0f\u20e3 L\u00f3pez-Ot\u00edn C. et al.
\nThe Hallmarks of Aging,
\nCell, 2013
\n\u2192 \u0160t\u00fadia identifikuj\u00faca metabolick\u00fa dysregul\u00e1ciu a mitochondri\u00e1lnu dysfunkciu ako k\u013e\u00fa\u010dov\u00e9 faktory biologick\u00e9ho starnutia, ktor\u00e9 s\u00fa cie\u013eom AMPK modul\u00e1cie.<\/p>\n
4\ufe0f\u20e3 Preklinick\u00e9 modely (in vitro \/ in vivo)
\nExperiment\u00e1lne \u0161t\u00fadie sleduj\u00face vplyv AICAR na bunkov\u00fd metabolizmus, autof\u00e1giu, energetick\u00fa rovnov\u00e1hu a adapt\u00e1ciu buniek na stres.<\/p>\n
Bezpe\u010dnostn\u00e1 a regula\u010dn\u00e1 inform\u00e1cia
\n\u26a0\ufe0f D\u00f4le\u017eit\u00e9 upozornenie:<\/p>\n
AICAR je ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny a v\u00fdskumn\u00fd \u00fa\u010del<\/p>\n
Nie je schv\u00e1len\u00fd ako liek<\/p>\n
Nie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie<\/p>\n
Nie je ur\u010den\u00fd na konzum\u00e1ciu alebo klinick\u00e9 aplik\u00e1cie<\/p>\n
Produkt je distribuovan\u00fd v\u00fdhradne pre v\u00fdskumn\u00e9 in\u0161tit\u00facie, laborat\u00f3ri\u00e1 a odborn\u00e9 experiment\u00e1lne pou\u017eitie.<\/p>\n","protected":false},"excerpt":{"rendered":"
AICAR je v\u00fdskumn\u00fd peptid pou\u017e\u00edvan\u00fd v laborat\u00f3rnych modeloch na \u0161t\u00fadium bunkovej energetiky, aktiv\u00e1cie AMPK dr\u00e1hy a mechanizmov spojen\u00fdch s metabolizmom a starnut\u00edm buniek.<\/p>\n
\u2705 Len na v\u00fdskumn\u00e9 \u00fa\u010dely
\n\u274c Nie je ur\u010den\u00fd na hum\u00e1nne pou\u017eitie<\/p>\n
Obsah:<\/strong> 50mg<\/p>\n","protected":false},"featured_media":1259,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[154,165],"product_tag":[],"class_list":["post-1258","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging","product_cat-regeneration","pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","pa_obsah-50mg","first","instock","purchasable","product-type-simple"],"yoast_head":"\n