BPC-157
\nV\u00fdskumn\u00fd peptid BPC-157 predstavuje potenci\u00e1lnu lie\u010div\u00fa zl\u00fa\u010deninu, ktor\u00e1 by po v\u00fdskume na \u013eu\u010foch mohla by\u0165 \u00faspe\u0161n\u00fdm liekom na mnoh\u00e9 druhy poranen\u00ed, vr\u00e1tane por\u00fach a r\u00e1n na org\u00e1noch, \u017e\u013eaz\u00e1ch \u010di ko\u017ei. T\u00fato \u010diasto\u010dn\u00fa sekvenciu z \u013eudsk\u00e9ho \u017eal\u00fado\u010dn\u00e9ho ochrann\u00e9ho prote\u00ednu BPC, ktor\u00fd sa prirodzene nach\u00e1dza v tr\u00e1viacom trakte \u010dloveka a bol z\u00edskan\u00fd z \u013eudsk\u00fdch \u017eal\u00fado\u010dn\u00fdch \u0161tiav, objavila v 90. rokoch 20. storo\u010dia skupina vedcov, ktor\u00ed sk\u00famali jeho vplyv najm\u00e4 na funkcie tr\u00e1viaceho traktu a hojenie r\u00e1n.<\/p>\n
V po\u010detn\u00fdch \u0161t\u00fadi\u00e1ch na kult\u00farach a zvierat\u00e1ch preuk\u00e1zal penta-decapeptid konzistentne pozit\u00edvne a r\u00fdchle hojiv\u00e9 \u00fa\u010dinky pri v\u00e4\u010d\u0161ine syst\u00e9mov\u00fdch alebo traumatick\u00fdch poranen\u00ed. Zistilo sa, \u017ee t\u00e1to vysok\u00e1 regenera\u010dn\u00e1 a hojiv\u00e1 schopnos\u0165 p\u00f4sob\u00ed nielen na mno\u017estvo m\u00e4kk\u00fdch tkan\u00edv, svalov a v\u00e4zov, ale aj na vn\u00fatorn\u00e9 org\u00e1ny, ko\u017eu, nervov\u00fd syst\u00e9m a lie\u010di probl\u00e9my ako vredy, Crohnovu chorobu alebo probl\u00e9my s nepriechodn\u00fdm \u010drevom. M\u00e1 tie\u017e analgetick\u00e9 \u00fa\u010dinky a zvy\u0161uje produkciu retikul\u00ednu a kolag\u00e9nu, angiogen\u00e9zu spolu so stimul\u00e1ciou infiltr\u00e1cie makrof\u00e1gov a fibroblastov. Okrem toho v\u00fdskumn\u00e9 \u0161t\u00fadie preuk\u00e1zali aj jeho schopnos\u0165 pom\u00e1ha\u0165 pri r\u00fdchlej\u0161om hojen\u00ed chemick\u00fdch pop\u00e1len\u00edn ko\u017ee t\u00fdm, \u017ee zvy\u0161uje prietok krvi do po\u0161koden\u00fdch tkan\u00edv.<\/p>\n
Napriek tomu, \u017ee st\u00e1le ch\u00fdbaj\u00fa klinick\u00e9 \u0161t\u00fadie na \u013eu\u010foch, peptid m\u00e1 ve\u013ek\u00fd potenci\u00e1l a \u010fal\u0161\u00ed v\u00fdvoj by mohol prinies\u0165 terapiu pre mnoh\u00e9 regenera\u010dn\u00e9 procesy. Nazrime teraz na niektor\u00e9 z\u00e1very v\u00fdskumn\u00fdch \u0161t\u00fadi\u00ed o BPC-157.<\/p>\n
[1]<\/p>\n
\u00da\u010dinky potvrden\u00e9 v\u00fdskumom
\n1. BPC-157 vo v\u00fdskume hojenia r\u00e1n
\nExistuje nieko\u013eko \u0161t\u00fadi\u00ed zameran\u00fdch na objasnenie presn\u00e9ho mechanizmu hojenia r\u00e1n prostredn\u00edctvom BPC-157. V\u00fdskum na samcoch potkanov \u0161tudoval \u00fa\u010dinok peptidu na fibroblastoch izolovan\u00fdch z Achillov\u00fdch \u0161liach. Pod\u013ea anal\u00fdzy cDNA microarray zv\u00fd\u0161il BPC-157 vo fibroblastoch \u0161\u013eachy expresiu receptora rastov\u00e9ho horm\u00f3nu. V pr\u00edpade fibroblastov ide o bunky, ktor\u00e9 s\u00fa neoddelite\u013enou s\u00fa\u010das\u0165ou hojenia r\u00e1n a s\u00fa zodpovedn\u00e9 za ukladanie prote\u00ednov extracelul\u00e1rnej matrice, ako s\u00fa kolag\u00e9n, fibr\u00edn, elast\u00edn at\u010f. Zistilo sa, \u017ee BPC-157 preuk\u00e1zate\u013ene ovplyv\u0148uje prolifer\u00e1ciu fibroblastov v kult\u00fare a in vivo v z\u00e1vislosti od d\u00e1vky a \u010dasu, v d\u00f4sledku \u010doho sa bunky mno\u017eia a migruj\u00fa r\u00fdchlej\u0161ie. Na potvrdenie v\u00fdsledkov boli fibroblasty zo \u0161liach o\u0161etren\u00e9 BPC-157 v r\u00f4znych koncentr\u00e1ci\u00e1ch v priebehu 24 hod\u00edn, \u010do uk\u00e1zalo, \u017ee expresia GH receptora sa zvy\u0161uje v\u010faka \u00fa\u010dinku z\u00e1visl\u00e9ho od d\u00e1vkovania, ktor\u00fd podporuje prolifer\u00e1ciu GH, \u010do by mohlo ma\u0165 potenci\u00e1lny lie\u010debn\u00fd efekt. Na tret\u00ed de\u0148 sa pozorovalo a\u017e sedemn\u00e1sobn\u00e9 zv\u00fd\u0161enie.<\/p>\n
BPC-157 sa sk\u00famal aj ako potenci\u00e1lne \u010dinidlo na lie\u010dbu chemicky pop\u00e1lenej ko\u017ee v hlboko po\u0161koden\u00fdch tkaniv\u00e1ch pri alkalick\u00fdch pop\u00e1lenin\u00e1ch potkanov. V\u00fdsledky uk\u00e1zali, \u017ee peptid by mohol ur\u00fdchli\u0165 proces hojenia mechanizmom spojen\u00fdm so zr\u00fdchlenou tvorbou granula\u010dn\u00e9ho tkaniva, reepiteliz\u00e1ciou, remodel\u00e1ciou ko\u017ee a ukladan\u00edm kolag\u00e9nu prostredn\u00edctvom sign\u00e1lnej dr\u00e1hy ERK1\/2.<\/p>\n
[1] [2]<\/p>\n
2. Vplyv BPC-157 na vaskul\u00e1rny rast a kolateraliz\u00e1ciu ciev
\nVaskul\u00e1rny rast zohr\u00e1va d\u00f4le\u017eit\u00fa \u00falohu pri raste tkan\u00edv, ako aj regener\u00e1cii tela, pri\u010dom s\u00favis\u00ed najm\u00e4 s v\u00fdvojom a rastom ciev. S vaskul\u00e1rnym rastom sa sp\u00e1jaj\u00fa r\u00f4zne fyziologick\u00e9 a patologick\u00e9 situ\u00e1cie, ako je hojenie r\u00e1n, rast n\u00e1dorov alebo regener\u00e1cia po zraneniach. \u0160t\u00fadie uk\u00e1zali, \u017ee BPC-157 je siln\u00fd angiog\u00e9nny faktor, ktor\u00fd stimuluje r\u00fdchlos\u0165 rastu a prolifer\u00e1ciu endotelov\u00fdch buniek. \u010cas\u0165 mechanizmu, ktor\u00fdm BPC-157 podporuje rast cievnych endotelov\u00fdch buniek, prebieha prostredn\u00edctvom stimul\u00e1cie povrchov\u00e9ho bunkov\u00e9ho receptora VEGFR2, ktor\u00fd je akt\u00edvny v sign\u00e1lnej dr\u00e1he oxidu dusnat\u00e9ho. \u0160t\u00fadia in vitro s pou\u017eit\u00edm \u013eudsk\u00fdch cievnych endotelov\u00fdch buniek \u010falej potvrdila zv\u00fd\u0161en\u00fa expresiu mRNA a prote\u00ednov VEGFR2, ale nie VEGF-A.<\/p>\n
V\u00fdskum na potkanoch sk\u00famal, \u010di sa duoden\u00e1lne l\u00e9zie vyvolan\u00e9 ve\u013ek\u00fdmi \u017eilov\u00fdmi okluziami daj\u00fa zmierni\u0165 peptidom BPC 157 bez oh\u013eadu na \u00fa\u010das\u0165 syst\u00e9mu oxidu dusnat\u00e9ho (NO), a dospel k z\u00e1veru, \u017ee peptid r\u00fdchlo zabr\u00e1nil okl\u00fazii a mohol tak zachr\u00e1ni\u0165 p\u00f4vodn\u00fd duoden\u00e1lny prietok. Stalo sa tak cez doln\u00fa predn\u00fa pankreatikoduoden\u00e1lnu \u017eilu na prietok hornou mezenterickou \u017eilou, \u010do je \u00fa\u010dinok s\u00favisiaci so syst\u00e9mom NO a zn\u00ed\u017een\u00edm tvorby vo\u013en\u00fdch radik\u00e1lov.<\/p>\n
Tento stabiln\u00fd \u017eal\u00fado\u010dn\u00fd penta-decapeptid sa pou\u017eil aj na z\u00edskanie nov\u00fdch poznatkov pre lie\u010dbu kolit\u00eddy a isch\u00e9mie a reperf\u00fazie u potkanov, kde sa uk\u00e1zalo, \u017ee dok\u00e1zal r\u00fdchlo obnovi\u0165 prekrvenie ischemicky po\u0161koden\u00fdch oblast\u00ed a stimulova\u0165 r\u00fdchlos\u0165 rastu kolater\u00e1lnych ciev zapojen\u00fdch do syst\u00e9mu NO. \u010eal\u0161\u00ed v\u00fdskum priniesol nov\u00fd poh\u013ead a uk\u00e1zal, \u017ee aplik\u00e1cia BPC 157 do zna\u010dnej miery zn\u00ed\u017eila alebo dokonca \u00faplne odstr\u00e1nila v\u0161etky n\u00e1sledky z\u00e1kroku podviazania dolnej dutinovej \u017eily u potkanov, ako je priame poranenie \u017eily, tromb\u00f3za, trombocytop\u00e9nia alebo pred\u013a\u017een\u00e9 krv\u00e1canie. \u010ealej je mo\u017en\u00e9 skon\u0161tatova\u0165, \u017ee BPC-157 zmier\u0148uje l\u00e9zie tr\u00e1viaceho traktu, ale aj l\u00e9zie pe\u010dene a mozgu, ako aj kardiovaskul\u00e1rneho, neurologick\u00e9ho a svalov\u00e9ho tkaniva. Existuj\u00fa o tom ur\u010dit\u00e9 d\u00f4kazy z v\u00fdskumu. BPC-157 aktivuje cievy, ktor\u00e9 prech\u00e1dzaj\u00fa po\u0161kodenou oblas\u0165ou a sfunk\u010d\u0148uje kolater\u00e1lne \u017eily \u2013 a obnovuje tak prietok krvi v po\u0161kodenej oblasti.<\/p>\n
[3]-[9]<\/p>\n
3. BPC-157 ako cytoprotekt\u00edvny medi\u00e1tor
\nBPC-157 je zn\u00e1my aj ako peptid proti vredovej chorobe, ktor\u00fd dok\u00e1\u017ee lie\u010di\u0165 a chr\u00e1ni\u0165 r\u00f4zne po\u0161kodenia telesn\u00fdch org\u00e1nov a z\u00e1rove\u0148 zachov\u00e1va prirodzen\u00fa integritu slizni\u010dnej bari\u00e9ry v tr\u00e1viacom trakte. Tento peptid p\u00f4sob\u00ed vo ve\u013ekom rozsahu a m\u00e1 dokonca ove\u013ea priaznivej\u0161ie \u00fa\u010dinky ako \u0161tandardn\u00e9 cytoprotekt\u00edva. BPC 157, ako prototyp cytoprotekt\u00edvnej l\u00e1tky, by tak mal kontrolova\u0165 funkciu ciev v z\u00e1vislosti od poranenia, perforovan\u00e9ho defektu alebo cievnej ob\u0161trukcie.<\/p>\n
[9]<\/p>\n
4. Hojenie \u0161liach pomocou BPC-157
\nPoranenia \u0161liach s\u00fa obzvl\u00e1\u0161\u0165 \u010dast\u00e9 a ich hojenie je ve\u013eakr\u00e1t \u0165a\u017ek\u00e9 a ve\u013emi pomal\u00e9. Navy\u0161e, zahojen\u00e9 \u0161\u013eachy s\u00fa zvy\u010dajne slab\u0161ie ako pred zranen\u00edm. Preto je d\u00f4le\u017eit\u00e9 vyvin\u00fa\u0165 nov\u00fa terapeutick\u00fa lie\u010dbu. BPC-157 ur\u00fdch\u013euje z\u00edskavanie fibroblastov a pr\u00edvod krvi do poranen\u00fdch tkan\u00edv, podporuje regener\u00e1ciu r\u00e1n v \u0161\u013each\u00e1ch, v\u00e4ziv\u00e1ch, svaloch a kostiach, \u010do bolo preuk\u00e1zan\u00e9 in vitro a in vivo v\u00fdskumom na \u0161\u013each\u00e1ch potkanov. V\u00fdskum dospel k z\u00e1veru, \u017ee peptid bol \u00fa\u010dinnej\u0161\u00ed ako horm\u00f3ny bFGF, EFG a VGF pri podpore hojenia tkan\u00edv a vhodne implementoval svoj vlastn\u00fd angiog\u00e9nny hojiv\u00fd \u00fa\u010dinok.<\/p>\n
Okrem toho je BPC-157 siln\u00fdm stimul\u00e1torom produkcie F-akt\u00ednu vo fibroblastoch, \u010do bolo odhalen\u00e9 experimentmi s pou\u017eit\u00edm farbenia FITC-faloid\u00ednom a anal\u00fdza pomocou Western blottingu uk\u00e1zala, \u017ee BPC-157 zvy\u0161uje fosforyl\u00e1ciu prote\u00ednov paxil\u00ednu a FAK \u2013 kritick\u00fdch prote\u00ednov v dr\u00e1ha bunkovej migr\u00e1cie. Z\u00e1verom sa d\u00e1 poveda\u0165, \u017ee BPC 157 podporuje ex vivo rast \u0161\u013eachov\u00fdch fibroblastov zo \u0161\u013eachov\u00fdch explant\u00e1tov, pre\u017e\u00edvanie buniek v strese a in vitro migr\u00e1ciu \u0161\u013eachov\u00fdch fibroblastov, ktor\u00e1 je pravdepodobne sprostredkovan\u00e1 aktiv\u00e1ciou FAK-paxil\u00ednovej dr\u00e1hy.<\/p>\n
[10], [11], [12]<\/p>\n
5. Potenci\u00e1lne antioxida\u010dn\u00e9 \u00fa\u010dinky BPC-157
\nPeptid BPC-157 sa tie\u017e jav\u00ed ako siln\u00fd antioxidant, ktor\u00fd m\u00f4\u017ee neutralizova\u0165 markery oxida\u010dn\u00e9ho stresu, ako je oxid dusnat\u00fd (NO) a malondialdehyd (MDA). V\u00fdskum na potkanoch uk\u00e1zal, \u017ee m\u00f4\u017ee zn\u00ed\u017ei\u0165 produkciu reakt\u00edvnych foriem kysl\u00edka v GI trakte.<\/p>\n
Bakt\u00e9rie mlie\u010dneho kvasenia sa sk\u00famali ako vhodn\u00fd prostriedok, ako dosta\u0165 terapeutick\u00e9 prote\u00edny alebo peptidy na povrchy slizn\u00edc v organizme. BPC-157 je schopn\u00fd predch\u00e1dza\u0165 a lie\u010di\u0165 gastrointestin\u00e1lny z\u00e1pal zn\u00ed\u017een\u00edm produkcie reakt\u00edvnych foriem kysl\u00edka. V tejto \u0161t\u00fadii sa Lactococcus lactis bakt\u00e9rie pou\u017eili ako prostredn\u00edk na dopravenie peptidu BPC-157 na povrch GI.<\/p>\n
[3], [13]<\/p>\n
6. BPC-157 eliminuje ved\u013eaj\u0161ie \u00fa\u010dinky niektor\u00fdch liekov
\n\u010eal\u0161\u00edm potenci\u00e1lnym pr\u00ednosom, ktor\u00fd m\u00e1 peptid BPC-157, je p\u00f4sobenie proti ved\u013eaj\u0161\u00edm \u00fa\u010dinkom ur\u010dit\u00fdch liekov. Ide najm\u00e4 o nesteroidn\u00e9 protiz\u00e1palov\u00e9 lieky (NSAID), lieky pod\u00e1van\u00e9 pri psychiatrick\u00fdch ochoreniach alebo lieky na srdce, neuroleptik\u00e1 a prokinetik\u00e1. Kv\u00f4li z\u00e1va\u017en\u00fdm ved\u013eaj\u0161\u00edm \u00fa\u010dinkom sa mnoh\u00e9 nem\u00f4\u017eu u\u017e\u00edva\u0165 dlhodobo. Peptid v\u0161ak pom\u00e1ha eliminova\u0165 ved\u013eaj\u0161ie \u00fa\u010dinky p\u00f4sobiace nielen na GI trakt, ale aj na mozog, srdce \u010di in\u00e9 tkaniv\u00e1, \u010do op\u00e4\u0165 potvrdili \u0161t\u00fadie na zvierat\u00e1ch.<\/p>\n
Zvl\u00e1\u0161\u0165 zauj\u00edmav\u00e9 je p\u00f4sobenie BPC-157 v kontexte srdcov\u00fdch arytmi\u00ed. Neuroleptik\u00e1 a prokinetik\u00e1 be\u017ene vyvol\u00e1vaj\u00fa pred\u013a\u017een\u00fd QTc interval. Peptid skuto\u010dne m\u00f4\u017ee pom\u00f4c\u0165 chr\u00e1ni\u0165 pred pred\u013a\u017een\u00edm QTc stavu srdca u potkanov pri dennom pod\u00e1van\u00ed dopam\u00ednov\u00fdch neurolept\u00edk alebo prokinet\u00edk, \u010do m\u00f4\u017ee vies\u0165 k z\u00e1va\u017en\u00fdm alebo dokonca fat\u00e1lnym arytmi\u00e1m. U potkanov a my\u0161\u00ed BPC 157 tie\u017e p\u00f4sobil proti katalepsii vyvolanej neuroleptikami a \u017eal\u00fado\u010dn\u00fdm vredom. St\u00e1va sa to napr\u00edklad aj pri u\u017e\u00edvan\u00ed liekov na cukrovku, schizofr\u00e9niu a in\u00e9 psychick\u00e9 stavy. Uk\u00e1zalo sa, \u017ee plne interaguje s dopam\u00ednov\u00fdm syst\u00e9mom, centr\u00e1lne a perif\u00e9rne.<\/p>\n
[14], [15]<\/p>\n
7. P\u00f4sobenie BPC-157 na v\u010dely
\nExperimenty s peror\u00e1lnym pod\u00e1van\u00edm cukrov\u00e9ho sirupu s BPC-157 do GI traktu v\u010diel medonosn\u00fdch zaznamenali pozit\u00edvne \u00fa\u010dinky na inv\u00e1zie Nosema Ceranae a takzvan\u00fd CCD syndr\u00f3m poruchy zr\u00fatenia kol\u00f3ni\u00ed. Predpoklad\u00e1 sa v\u0161ak, \u017ee pr\u00ed\u010dinou tohto ochorenia by mohla by\u0165 infekcia v \u010dreve v\u010diel sp\u00f4soben\u00e1 pr\u00e1ve hubou Nosema ceranae, ktor\u00e1 \u010dasto zapr\u00ed\u010di\u0148uje obrovsk\u00e9 \u0161kody a \u00fahyn cel\u00fdch kol\u00f3ni\u00ed v\u010diel. Doplnenie stravy v\u010diel o BPC-157 po\u010das 21 po sebe nasleduj\u00facich dn\u00ed zn\u00ed\u017eilo po\u0161kodenie, a to najm\u00e4 po\u0161kodenie vonkaj\u0161ieho svalov\u00e9ho pl\u00e1\u0161\u0165a, a zv\u00fd\u0161ilo mieru pre\u017eitia kol\u00f3ni\u00ed na poli.<\/p>\n
[16]<\/p>\n
8. Z\u00e1ver
\nBPC-157 je predmetom v\u00fdskumu bunkov\u00fdch kult\u00far, najm\u00e4 u zvierat, a vyzer\u00e1 ve\u013emi s\u013eubne nielen ako terapeutick\u00e9 \u010dinidlo na hojenie r\u00e1n alebo regul\u00e1ciu vaskul\u00e1rneho rastu, ale aj ako n\u00e1stroj na podrobn\u00e9 presk\u00famanie t\u00fdchto procesov. \u010eal\u0161\u00ed v\u00fdskum na \u013eu\u010foch by bol ve\u013emi priazniv\u00fd. Peptid by tie\u017e mohol vnies\u0165 viac svetla do procesu angiogen\u00e9zy, ktor\u00fd je d\u00f4le\u017eit\u00fd pri hojen\u00ed r\u00e1n, ale aj pri raste a v\u00fdvoji rakoviny a pri embryogen\u00e9ze. U my\u0161\u00ed m\u00e1 peptid minim\u00e1lne ved\u013eaj\u0161ie \u00fa\u010dinky.<\/p>\n","protected":false},"excerpt":{"rendered":"
BPC-157, synteticky vyroben\u00fd penta-dekapeptid, fragment prote\u00ednu Body Protective Compound (BPC), ktor\u00fd bol objaven\u00fd a izolovan\u00fd z \u013eudskej \u017eal\u00fado\u010dnej \u0161\u0165avy, predstavuje sekvenciu 15 aminokysel\u00edn podobn\u00fa tej, ktor\u00e1 sa nach\u00e1dza v \u013eudskom BPC. Vo viacer\u00fdch v\u00fdskumn\u00fdch \u0161t\u00fadi\u00e1ch na zvierat\u00e1ch a kultivovan\u00fdch bunk\u00e1ch sa uk\u00e1zalo, \u017ee tento peptid ur\u00fdch\u013euje hojenie r\u00f4znych druhov r\u00e1n v tkaniv\u00e1ch, vr\u00e1tane \u0161liach, svalov, k\u013abov, v\u00e4zov a m\u00e1 pozit\u00edvne \u00fa\u010dinky aj na z\u00e1palov\u00e9 ochorenia \u010driev, in\u00e9 \u010drevn\u00e9 probl\u00e9my, vredy, poko\u017eku alebo dokonca nervov\u00fd syst\u00e9m a cievy. Tento peptid dok\u00e1\u017ee zv\u00fd\u0161i\u0165 a ur\u00fdchli\u0165 prietok krvi v oblasti poranen\u00ed, ktor\u00fd je za norm\u00e1lnych okolnost\u00ed ve\u013emi pomal\u00fd, a je preto ve\u013emi \u00fa\u010dinn\u00fd v ur\u00fdch\u013eovan\u00ed procesoch hojenia.<\/p>\n","protected":false},"featured_media":1380,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[165],"product_tag":[],"class_list":["post-1379","product","type-product","status-publish","has-post-thumbnail","product_cat-regeneration","pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","pa_obsah-10mg","pa_obsah-500mcg","pa_obsah-5mg","first","instock","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"\n