{"id":3030,"date":"2026-03-04T10:57:23","date_gmt":"2026-03-04T09:57:23","guid":{"rendered":"https:\/\/www.royalpeptides.eu\/?post_type=product&p=3030"},"modified":"2026-04-15T23:56:14","modified_gmt":"2026-04-15T21:56:14","slug":"ace031ae1","status":"publish","type":"product","link":"https:\/\/www.royalpeptides.eu\/ro\/produkt\/ace031ae1","title":{"rendered":"ACE031(AE1)"},"content":{"rendered":"

ACE-031 (AE1) \u2013 protein de fuziune recombinant de cercetare, orientat c\u0103tre reglarea cre\u0219terii musculare \u0219i semnalizarea TGF-\u03b2<\/p>\n

ACE-031 (AE1) este un protein de fuziune recombinant, dezvoltat ca instrument experimental pentru studierea regl\u0103rii masei musculare prin modularea c\u0103ilor de semnalizare din superfamilia TGF-\u03b2 (transforming growth factor beta). \u00cen modelele preclinice \u0219i experimentale, este obiectul cercet\u0103rii \u00een special \u00een domeniul inhib\u0103rii miostatinei \u0219i al altor liganzi de tip activin\u0103, implica\u021bi \u00een reglarea cre\u0219terii \u0219i diferen\u021bierii mu\u0219chiului scheletic.<\/p>\n

Face parte dintre moleculele biologice studiate \u00een contextul regl\u0103rii moleculare a hipertrofiei musculare, prolifer\u0103rii celulare \u0219i adapt\u0103rii metabolice a celulelor musculare.<\/p>\n

De ce este ACE-031 obiect de cercetare<\/p>\n

ACE-031 permite cercet\u0103torilor s\u0103 analizeze mecanismele de reglare a masei musculare la nivelul leg\u0103rii receptorilor \u0219i al semnaliz\u0103rii intracelulare ulterioare. Este studiat \u00een special \u00een leg\u0103tur\u0103 cu:<\/p>\n

\u2022 inhibarea semnaliz\u0103rii miostatinei
\n\u2022 modularea receptorilor de activin\u0103 de tip IIB (ActRIIB)
\n\u2022 reglarea diferen\u021bierii \u0219i prolifer\u0103rii mioblastelor
\n\u2022 mecanismele hipertrofiei musculare
\n\u2022 adaptarea metabolic\u0103 a mu\u0219chiului scheletic
\n\u2022 interac\u021biunea dintre factorii de cre\u0219tere \u0219i semnalizarea extracelular\u0103<\/p>\n

\u00cen modelele experimentale, serve\u0219te ca instrument pentru studierea proceselor biologice care influen\u021beaz\u0103 volumul, structura \u0219i capacitatea func\u021bional\u0103 a \u021besutului muscular.<\/p>\n

Mecanism de ac\u021biune (context de cercetare)<\/p>\n

ACE-031 este conceput ca un protein de fuziune care con\u021bine domeniul extracelular al receptorului ActRIIB, capabil s\u0103 lege liganzi apar\u021bin\u00e2nd superfamiliei TGF-\u03b2, inclusiv miostatina. Prin legarea acestor liganzi poate avea loc reducerea disponibilit\u0103\u021bii lor biologice \u0219i modularea ulterioar\u0103 a c\u0103ilor de semnalizare downstream, \u00een special mecanismele SMAD-dependente.<\/p>\n

Studiile de laborator sugereaz\u0103 c\u0103 astfel de molecule pot influen\u021ba:<\/p>\n

\u2022 expresia genelor implicate \u00een reglarea cre\u0219terii musculare
\n\u2022 echilibrul dintre proteosintez\u0103 \u0219i proteoliz\u0103
\n\u2022 diferen\u021bierea celulelor satelit musculare
\n\u2022 c\u0103ile de semnalizare care regleaz\u0103 ciclul celular
\n\u2022 organizarea structural\u0103 a fibrelor musculare<\/p>\n

Aceste procese sunt importante pentru \u00een\u021belegerea regl\u0103rii moleculare a masei musculare \u00een condi\u021bii experimentale.<\/p>\n

Domenii de utilizare \u00een cercetare<\/p>\n

ACE-031 este utilizat \u00een principal \u00een domeniile:<\/p>\n

\u2022 cercetarea regl\u0103rii hipertrofiei musculare
\n\u2022 biologia molecular\u0103 a mu\u0219chiului scheletic
\n\u2022 studiul semnaliz\u0103rii TGF-\u03b2 \u0219i miostatinei
\n\u2022 diferen\u021bierea \u0219i proliferarea celular\u0103 a mioblastelor
\n\u2022 modele experimentale de atrofie \u0219i adaptare muscular\u0103<\/p>\n

Baz\u0103 \u0219tiin\u021bific\u0103 \u0219i surse de cercetare<\/p>\n

Cercetarea inhibi\u021biei miostatinei \u0219i a semnaliz\u0103rii ActRIIB se bazeaz\u0103 pe cuno\u0219tin\u021be \u0219tiin\u021bifice extinse privind reglarea cre\u0219terii musculare:<\/p>\n

1\ufe0f\u20e3 Lee S.J.
\nRegulation of muscle mass by myostatin
\nAnnual Review of Cell and Developmental Biology
\n\u2192 Rolul miostatinei \u00een reglarea masei musculare.<\/p>\n

2\ufe0f\u20e3 McPherron A.C. et al.
\nRegulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
\nNature
\n\u2192 Identificarea miostatinei \u0219i func\u021bia sa biologic\u0103.<\/p>\n

3\ufe0f\u20e3 Tendin\u021be \u00een cercetarea inhibitorilor ActRIIB
\nModele preclinice care investigheaz\u0103 modularea semnaliz\u0103rii SMAD \u0219i hipertrofia muscular\u0103.<\/p>\n

Informa\u021bii de siguran\u021b\u0103 \u0219i reglementare<\/p>\n

\u26a0\ufe0f Avertisment important:<\/p>\n

ACE-031 este destinat exclusiv utiliz\u0103rii \u00een laborator \u0219i cercet\u0103rii \u0219tiin\u021bifice.
\nNu este aprobat ca medicament.
\nNu este destinat utiliz\u0103rii umane sau veterinare.
\nNu este destinat consumului sau aplica\u021biilor clinice.<\/p>\n

Produsul este distribuit exclusiv institu\u021biilor de cercetare, laboratoarelor \u0219i utiliz\u0103rii experimentale specializate.<\/p>\n","protected":false},"excerpt":{"rendered":"

ACE-031 (AE1) este un protein de fuziune recombinant, destinat utiliz\u0103rii \u00een cercetare \u00een domeniul regl\u0103rii cre\u0219terii musculare \u0219i al semnaliz\u0103rii superfamiliei TGF-\u03b2 (transforming growth factor beta). \u00cen modelele experimentale este utilizat pentru studiul mecanismelor de inhibare a miostatinei \u0219i al efectelor acesteia asupra diferen\u021bierii musculare, hipertrofiei \u0219i adapt\u0103rii metabolice a mu\u0219chiului scheletic.<\/p>\n

Este studiat \u00een special \u00een contextul regl\u0103rii moleculare a masei musculare, al semnaliz\u0103rii celulare \u0219i al interac\u021biunii dintre factorii de cre\u0219tere \u0219i \u021besutul muscular.<\/p>\n

\u2705 Doar pentru scopuri de cercetare
\n\u274c Nu este destinat utiliz\u0103rii umane<\/p>\n","protected":false},"featured_media":3029,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[250,246,251],"product_tag":[],"class_list":{"0":"post-3030","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-aging","7":"product_cat-echilibru-hormonal","8":"product_cat-fitness","9":"pa_dolezite-upozornenie-vsetky-produkty-dostupne-v-nasej-ponuke-su-urcene-vyhradne-na-vyskumne-laboratorne-a-vyvojove-ucely-nie-su-urcene-na-pouzitie-ako-liek-zdravotnicka-pomocka-kozmeticky-pripra","10":"pa_obsah-1mg","12":"first","13":"instock","14":"purchasable","15":"product-type-simple"},"yoast_head":"\nACE031(AE1) - Royal Peptides<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.royalpeptides.eu\/ro\/produkt\/ace031ae1\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ACE031(AE1) - Royal Peptides\" \/>\n<meta property=\"og:description\" content=\"ACE-031 (AE1) este un protein de fuziune recombinant, destinat utiliz\u0103rii \u00een cercetare \u00een domeniul regl\u0103rii cre\u0219terii musculare \u0219i al semnaliz\u0103rii superfamiliei TGF-\u03b2 (transforming growth factor beta). \u00cen modelele experimentale este utilizat pentru studiul mecanismelor de inhibare a miostatinei \u0219i al efectelor acesteia asupra diferen\u021bierii musculare, hipertrofiei \u0219i adapt\u0103rii metabolice a mu\u0219chiului scheletic. 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