5-Amino

Description

5-Amino-1MQ – Research Molecule Focused on Metabolic Regulation

5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small molecule investigated in the field of cellular metabolism, energy homeostasis, and regulation of enzymatic activity. It belongs to the class of experimental inhibitors of the enzyme nicotinamide N-methyltransferase (NNMT), which is involved in nicotinamide metabolism and regulation of cellular energy status.

In research settings, 5-Amino-1MQ is of particular interest in the areas of metabolic signaling, adipocyte regulation, mitochondrial function, and molecular mechanisms influencing cellular energy balance.

Why 5-Amino-1MQ Is Studied

5-Amino-1MQ enables researchers to analyze several biological processes, particularly:

• regulation of NNMT enzyme activity
• nicotinamide metabolism and NAD+ pathways
• energy metabolism in adipocytes
• signaling mechanisms associated with cellular proliferation
• molecular processes related to regulation of body composition in experimental models

Mechanism of Action (Research Context)

In experimental models, 5-Amino-1MQ is investigated as a selective inhibitor of NNMT. The NNMT enzyme plays a role in nicotinamide methylation and influences NAD+ availability, which is essential for cellular energy metabolism and mitochondrial function.

Inhibition of NNMT may, under experimental conditions, lead to:

• increased availability of nicotinamide
• modulation of NAD+ metabolism
• influence on mitochondrial activity
• regulation of gene expression associated with energy metabolism

Laboratory studies suggest that these mechanisms may be relevant for understanding the regulation of metabolic balance and cellular energy dynamics.

Research Applications

5-Amino-1MQ is primarily used in the following research areas:

• metabolic regulation research
• study of NNMT enzymatic activity
• adipocyte cellular biology
• NAD+ metabolism research
• molecular mechanisms of energy homeostasis

Scientific Background and References

The application of 5-Amino-1MQ is based on broader research on NNMT and metabolic regulation:

1️⃣ Kraus D. et al.
Nicotine-methyltransferase regulates energy metabolism in adipose tissue
Nature Medicine, 2014
→ Role of NNMT in regulation of adipocyte energy metabolism.

2️⃣ Parsons R.B. et al.
The emerging role of nicotinamide N-methyltransferase in cancer and metabolism
Biochemical Journal, 2011
→ Overview of NNMT function in cellular metabolism.

3️⃣ Ulanovskaya O.A. et al.
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
Nature Chemical Biology, 2013
→ Mechanisms by which NNMT influences metabolic and epigenetic processes.

4️⃣ Preclinical and in vitro models
Studies focused on NAD+ metabolism, mitochondrial activity, and regulation of energy balance.

Safety and Regulatory Information

⚠️ Important Notice:

5-Amino-1MQ is intended strictly for laboratory and research purposes only.
It is not approved as a medicinal product.
It is not intended for human or veterinary use.
It is not intended for consumption or clinical application.

The product is distributed exclusively to research institutions, laboratories, and for professional experimental use only.

All products available in our offer are intended strictly for research, laboratory, and development purposes only. They are not intended for use as a medicinal product, medical device, cosmetic product, food, dietary supplement, or as an active substance intended for consumption or application in humans or animals.

These products are not approved for clinical use and must not be used for the diagnosis, treatment, or prevention of any disease.

By purchasing the product, the customer acknowledges and confirms understanding of its research nature and agrees to use it exclusively in accordance with this intended purpose.

The purchase of our products is permitted only to individuals over 18 years of age.

Product images are for illustrative purposes only. The actual appearance of the packaging may vary depending on the current batch.